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PMID: 1534212 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Effectiveness of dehydroepiandrosterone in reduction of cryptosporidial activity in immunosuppressed rats.

Antimicrobial agents and chemotherapy ·Vol. 36 ·No. 1 ·1992-01-00 ·Pages 220-2

Rasmussen KR, Arrowood MJ, Healey MC

Abstract

The aim of this study was to evaluate the efficacy of the immunomodulator dehydroepiandrosterone in the treatment of cryptosporidiosis in glucocorticoid-induced immunosuppressed rats. A significant reduction in cryptosporidial activity occurred in treated versus untreated rats as assessed by oocyst shedding intensities and examination of parasite colonization in the small intestine.

MeSH Terms
Animals Cryptosporidiosis/drug therapy,immunology Cryptosporidium parvum/drug effects Dehydroepiandrosterone/therapeutic use Dexamethasone/administration & dosage Female Ileum/parasitology,pathology Immunosuppression Therapy Rats Rats, Inbred Strains
Chemicals
Dehydroepiandrosterone Dexamethasone
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Rasmussen K R
Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan 84322-5600.
Arrowood M J
Healey M C
References (10)
10 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.36.1.220
Published
1992-01-00
Pages
220-2
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC189268
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.36.1.220 PMC Full Text View journal details
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