DAT1, DRD4, and DRD5 polymorphisms are not associated with ADHD in Dutch families.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics ·Vol. 132B ·No. 1 ·2005-01-05 ·Pages 50-2

Bakker SC, van der Meulen EM, Oteman N, Schelleman H, Pearson PL, Buitelaar JK, Sinke RJ

Abstract

Recent meta-analyses have indicated that the dopamine transporter gene (DAT1) and the dopamine receptor genes D4 (DRD4) and D5 (DRD5) are associated with attention-deficit hyperactivity disorder (ADHD), although single studies frequently failed to show significant association. In a family-based sample of 236 Dutch children with ADHD, we have investigated the previously described variable number of tandem repeat (VNTR) polymorphisms and two additional microsatellites at the DAT1 and DRD4 loci. DRD5 was investigated using the microsatellite that was previously found to be associated. Transmission disequilibrium tests (TDTs) did not show preferential transmission of alleles or two-marker haplotypes to affected offspring. These data suggest that DAT1, DRD4, and DRD5 do not contribute substantially to ADHD in the Dutch population.

MeSH Terms

Alleles Attention Deficit Disorder with Hyperactivity/genetics Dopamine Plasma Membrane Transport Proteins Family Health Female Gene Frequency Haplotypes Humans Linkage Disequilibrium Logistic Models Male Membrane Glycoproteins/genetics Membrane Transport Proteins/genetics Microsatellite Repeats/genetics Minisatellite Repeats/genetics Nerve Tissue Proteins/genetics Netherlands Polymorphism, Genetic Receptors, Dopamine D1/genetics Receptors, Dopamine D2/genetics Receptors, Dopamine D4 Receptors, Dopamine D5

Chemicals

DRD4 protein, human DRD5 protein, human Dopamine Plasma Membrane Transport Proteins Membrane Glycoproteins Membrane Transport Proteins Nerve Tissue Proteins Receptors, Dopamine D1 Receptors, Dopamine D2 SLC6A3 protein, human Receptors, Dopamine D4 Receptors, Dopamine D5

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Bakker Steven C

Department of Psychiatry, A 00.241, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands. [email protected]

van der Meulen Emma M

Oteman Nicole

Schelleman Hedi

Pearson Peter L

Buitelaar Jan K

Sinke Richard J

Article Info

Journal

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

Abbr.

Am J Med Genet B Neuropsychiatr Genet

ISSN

1552-4841

DOI

10.1002/ajmg.b.30089

[email protected]

Published

2005-01-05

Pages

50-2

Language