Immuno-chemical studies on blood groups; the preparation of blood group A and B substances and an inactive substance from individual horse stomachs and of blood group B substance from human saliva.

The Journal of experimental medicine ·Vol. 91 ·No. 1 ·1950-01-01 ·Pages 105-14

BAER H, KABAT EA, KNAUB V

Abstract

Blood group substances have been isolated from the saliva of human beings of blood group B and from the linings of individual horse stomachs. The properties of the human B substances are similar to those of hog and human blood group substances previously isolated. The horse substances showed lower hexosamine and reducing sugar and higher total and non-hexosamine nitrogen than do the materials from the other species. Materials isolated from individual horse stomachs possess either A or B activity or both. Certain stomachs yielded products of identical analytical composition but with neither blood group A, B, or O activity as measured by their ability to inhibit isoagglutination. Fucose has been identified as a constituent of the horse blood group substances.

Keywords

BLOOD

MeSH Terms

Animals Blood Blood Group Antigens Horses Humans Saliva Stomach

Chemicals

Blood Group Antigens

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

BAER H

KABAT E A

KNAUB V

References (10)

10 references, click to expand

Filter-paper partition chromatography of sugars: 2. An examination of the blood group A specific substance from hog gastric mucin and the specific polysaccharide of Bacterium dysenteriae (Shiga).
Biochem J. 1948;42(2):251-3 PMID: 16748274
IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : IV. PREPARATION OF BLOOD GROUP A SUBSTANCES FROM HUMAN SOURCES AND A COMPARISON OF THEIR CHEMICAL AND IMMUNOCHEMICAL PROPERTIES WITH THOSE OF THE BLOOD GROUP A SUBSTANCE FROM HOG STOMACH.
J Exp Med. 1947 May 31;85(6):685-99 PMID: 19871643
Chemistry of tissues: 2. Polysaccharides showing blood group A-specificity and the nature of the constituent units of the stable carbohydrate residue of the A substance from pepsin.
Biochem J. 1946;40(1):124-30 PMID: 16747959
THE ISOLATION OF THE BLOOD GROUP SPECIFIC B SUBSTANCE.
J Exp Med. 1940 Nov 30;72(6):663-7 PMID: 19871051
Immunochemical studies on blood groups; chemical changes associated with destruction of blood group activity and enhancement of the type XIV cross-reactivity by partial hydrolysis of hog and human blood group A, B, and O substances.
J Exp Med. 1948 Jul;88(1):43-57 PMID: 18871876
Immunochemical studies on blood groups; the cross reaction between type XIV antipneumococcal horse serum and purified blood group A, B, and O substances from hog and human sources.
J Exp Med. 1948 Apr 1;87(4):295-300 PMID: 18904215
ON THE GROUP SPECIFIC A SUBSTANCE IN HORSE SALIVA. II.
J Exp Med. 1936 Jan 31;63(2):185-90 PMID: 19870466
Studies in immunochemistry: 7. The isolation from hog gastric mucin of the polysaccharide-amino acid complex possessing blood group A specificity.
Biochem J. 1943;37(5):640-51 PMID: 16747710
IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS : III. PROPERTIES OF PURIFIED BLOOD GROUP A SUBSTANCES FROM INDIVIDUAL HOG STOMACH LININGS.
J Exp Med. 1946 May 31;83(6):485-97 PMID: 19871545
The Lewis blood group characters of erythrocytes and body-fluids.
Br J Exp Pathol. 1949 Jun;30(3):198-208 PMID: 18136786

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.91.1.105

Published

1950-01-01

Pages

105-14

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2135944

Subset

External Links

PubMed source DOI: 10.1084/jem.91.1.105 PMC Full Text View journal details

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Immuno-chemical studies on blood groups; the preparation of blood group A and B substances and an inactive substance from individual horse stomachs and of blood group B substance from human saliva.

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