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PMID: 1542679 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Cortical local circuit axons do not mature after early deafferentation.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 89 ·No. 5 ·1992-03-01 ·Pages 1832-6

McCasland JS, Bernardo KL, Probst KL, Woolsey TA

Abstract

The processes underlying development, refinement, and retention of the intracortical connections critical for the function of the mammalian brain are unknown. Horseradish peroxidase-labeled fibers in mouse somatosensory barrel cortex, which is patterned like the whiskers on the contralateral face from which it receives inputs, were evaluated by automated image analysis. The sensory nerve to the whiskers was sectioned on postnatal day 7, after the whisker map is set. The deprived barrel cortices, examined in adults, showed drastically diminished intracortical projections relative to normal controls, although the map of the whiskers in the cortex was unchanged. This demonstrates anatomically that the normal pattern of intracortical connections, like the normal sensory map, is dependent upon the sensory periphery four synapses away.

MeSH Terms
Afferent Pathways/growth & development Age Factors Animals Denervation Mice Neuronal Plasticity Somatosensory Cortex/anatomy & histology,growth & development Trigeminal Nerve/growth & development Vibrissae/innervation
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
McCasland J S
Division of Experimental Neurology and Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110.
Bernardo K L
Probst K L
Woolsey T A
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.89.5.1832
Published
1992-03-01
Pages
1832-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC48547
Subset
IM
Grants
NINDS NIH HHS · NS17763 · United States
External Links
PubMed source DOI: 10.1073/pnas.89.5.1832 PMC Full Text View journal details
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