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PMID: 15453906 Published · ppublish English Journal Article Review

Hide and seek: the secret identity of the phosphatidylserine receptor.

Journal of biology ·Vol. 3 ·No. 4 ·2004-00-00 ·Pages 14

Williamson P, Schlegel RA

Abstract

Phosphatidylserine on the dying cell surface helps identify apoptotic cells to phagocytes, which then engulf them. A candidate phagocyte receptor for phosphatidylserine was identified using phage display, but the phenotypes of knockout mice lacking this presumptive receptor, as well as the location of the protein within cells, cast doubt on the assignment of this protein as the phosphatidylserine receptor.

MeSH Terms
Animals Apoptosis Gene Deletion Mice Mice, Knockout Receptors, Cell Surface/analysis,genetics,physiology
Chemicals
Ptdsr protein, mouse Receptors, Cell Surface phosphatidylserine receptor
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Williamson Patrick
Department of Biology, Amherst College, MA 01002, USA.
Schlegel Robert A
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22 references, click to expand
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Article Info
Journal
Journal of biology
Abbr.
J Biol
ISSN
1475-4924
DOI
10.1186/jbiol14
Published
2004-00-00
Epub
2004-00-23
Pages
14
Language
English
Region
England
NLM ID
101147570
PMCID
PMC549716
Subset
IM
External Links
PubMed source DOI: 10.1186/jbiol14 PMC Full Text
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