Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.

Adolescent Alleles Amino Acid Sequence Amyloid Precursor Protein Secretases Aspartic Acid Endopeptidases Cell Cycle Cell Line, Tumor Child Dimerization Endopeptidases/metabolism Frameshift Mutation Humans Leukemia-Lymphoma, Adult T-Cell/genetics,metabolism Molecular Sequence Data Mutation Mutation, Missense Point Mutation Protease Inhibitors/pharmacology Protein Structure, Tertiary Receptor, Notch1 Receptors, Cell Surface/chemistry,genetics,metabolism Sequence Deletion Signal Transduction Transcription Factors/chemistry,genetics,metabolism

NOTCH1 protein, human Protease Inhibitors Receptor, Notch1 Receptors, Cell Surface Transcription Factors Amyloid Precursor Protein Secretases Endopeptidases Aspartic Acid Endopeptidases BACE1 protein, human