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PMID: 1547500 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase.

Cell ·Vol. 68 ·No. 6 ·1992-03-20 ·Pages 1007-19

Gaul U, Mardon G, Rubin GM

Abstract

A Drosophila gene with similarity to the mammalian Ras GTPase activating protein has been isolated in screens for mutations that affect eye development. Inactivation of the locus, Gap1, mimics constitutive activation of the Sevenless receptor tyrosine kinase and eliminates the need for a functional Sevenless protein in the R7 cell. Our results suggest that Gap1 acts as a negative regulator of signaling by Sevenless by down-regulating the activity of the Ras1 protein, which has been shown to be a key element in signaling by Sevenless.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Down-Regulation/genetics Drosophila Proteins Drosophila melanogaster/embryology,genetics Eye/embryology Eye Proteins/metabolism GTPase-Activating Proteins Gene Expression Regulation/genetics Genes, Regulator/genetics Genes, ras Membrane Glycoproteins/metabolism Models, Molecular Molecular Sequence Data Protein-Tyrosine Kinases/antagonists & inhibitors Proteins/genetics Receptor Protein-Tyrosine Kinases Sequence Alignment Signal Transduction/genetics ras GTPase-Activating Proteins

Chemicals

Drosophila Proteins Eye Proteins GTPase-Activating Proteins Membrane Glycoproteins Proteins ras GTPase-Activating Proteins Protein-Tyrosine Kinases Receptor Protein-Tyrosine Kinases sev protein, Drosophila

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Gaul U

Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720.

Mardon G

Rubin G M

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/0092-8674(92)90073-l

Published

1992-03-20

Pages

1007-19

Language

English

Region

United States

NLM ID

0413066

Subset

Databases

GENBANK

M86655, S72766, S72767, S72768, S72769, S72771, S78086, S78088, S78090, X63098

External Links

PubMed source DOI: 10.1016/0092-8674(92)90073-l View journal details

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A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase.

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