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PMID: 15479853 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus.

Journal of virology ·Vol. 78 ·No. 21 ·2004-11-00 ·Pages 12090-5

Marzi A, Gramberg T, Simmons G, Möller P, Rennekamp AJ, Krumbiegel M, Geier M, Eisemann J, Turza N, Saunier B, Steinkasserer A, Becker S, Bates P, Hofmann H, Pöhlmann S

Abstract

The lectins DC-SIGN and DC-SIGNR can augment viral infection; however, the range of pathogens interacting with these attachment factors is incompletely defined. Here we show that DC-SIGN and DC-SIGNR enhance infection mediated by the glycoprotein (GP) of Marburg virus (MARV) and the S protein of severe acute respiratory syndrome coronavirus and might promote viral dissemination. SIGNR1, a murine DC-SIGN homologue, also enhanced infection driven by MARV and Ebola virus GP and could be targeted to assess the role of attachment factors in filovirus infection in vivo.

MeSH Terms
Cell Adhesion Molecules/physiology Glycoproteins/physiology Lectins, C-Type/physiology Marburgvirus/physiology Membrane Glycoproteins/physiology Receptors, Cell Surface/physiology SARS Virus/physiology Spike Glycoprotein, Coronavirus Viral Envelope Proteins/physiology
Chemicals
CLEC4M protein, human Cell Adhesion Molecules DC-specific ICAM-3 grabbing nonintegrin Glycoproteins Lectins, C-Type Membrane Glycoproteins Receptors, Cell Surface Spike Glycoprotein, Coronavirus Viral Envelope Proteins spike glycoprotein, SARS-CoV spike protein, mouse hepatitis virus
Authors & Affiliations
15 authors, click to expand affiliations / ORCID
Marzi Andrea
Institute for Clinical and Molecular Virology, University Erlangen-Nürnberg, Nikolaus-Fiebiger-Center, Glückstrasse 6, D-91054 Erlangen, Germany.
Gramberg Thomas
Simmons Graham
Möller Peggy
Rennekamp Andrew J
Krumbiegel Mandy
Geier Martina
Eisemann Jutta
Turza Nadine
Saunier Bertrand
Steinkasserer Alexander
Becker Stephan
Bates Paul
Hofmann Heike
Pöhlmann Stefan
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.78.21.12090-12095.2004
Published
2004-11-00
Pages
12090-5
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC523257
Subset
IM
Grants
NIAID NIH HHS · R21 AI059172 · United States
External Links
PubMed source DOI: 10.1128/JVI.78.21.12090-12095.2004 PMC Full Text View journal details
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