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PMID: 15485587 Published · ppublish English Journal Article Review

Inflammation, insulin resistance, and obesity.

Current atherosclerosis reports ·Vol. 6 ·No. 6 ·2004-11-00 ·Pages 424-31

Ferroni P, Basili S, Falco A, Davì G

Abstract

Obesity, in particular visceral obesity, has strong associations with cardiovascular disease and is related to many factors that are constituents of the metabolic syndrome. Increasing evidence suggests that features of the metabolic syndrome, including visceral obesity, are associated with a low-grade inflammatory state. Indeed, visceral fat is a source of several molecules, such as leptin, adiponectin, tumor necrosis factor-alpha, and interleukin 6, that are collectively called adipokines. All of them may induce a proinflammatory state and oxidative damage, leading to initiation and progression of atherosclerosis. Reduced-energy diets might represent an effective and healthful approach for long-term weight loss in patients with metabolic syndrome by reducing the underlying inflammatory condition.

MeSH Terms
Arteriosclerosis/etiology,physiopathology Humans Inflammation/complications,physiopathology Metabolic Syndrome/complications,physiopathology Obesity/complications,physiopathology Oxidative Stress/physiology Weight Loss/physiology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Ferroni Patrizia
Department of Experimental Medicine & Pathology, University of Rome, Italy.
Basili Stefani
Falco Angela
Davì Giovanni
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Article Info
Journal
Current atherosclerosis reports
Abbr.
Curr Atheroscler Rep
ISSN
1523-3804
DOI
10.1007/s11883-004-0082-x
Published
2004-11-00
Pages
424-31
Language
English
Region
United States
NLM ID
100897685
Subset
IM
External Links
PubMed source DOI: 10.1007/s11883-004-0082-x View journal details
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