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PMID: 15486828 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A combined linkage-physical map of the human genome.

American journal of human genetics ·Vol. 75 ·No. 6 ·2004-12-00 ·Pages 1143-8

Kong X, Murphy K, Raj T, He C, White PS, Matise TC

Abstract

We have constructed de novo a high-resolution genetic map that includes the largest set, to our knowledge, of polymorphic markers (N=14,759) for which genotype data are publicly available; that combines genotype data from both the Centre d'Etude du Polymorphisme Humain (CEPH) and deCODE pedigrees; that incorporates single-nucleotide polymorphisms; and that also incorporates sequence-based positional information. The position of all markers on our map is corroborated by both genomic sequence and recombination-based data. This specific combination of features maximizes marker inclusion, coverage, and resolution, making this map uniquely suitable as a comprehensive resource for determining genetic map information (order and distances) for any large set of polymorphic markers.

MeSH Terms

Chromosome Mapping Databases, Genetic Genetic Markers/genetics Genome, Human Humans Physical Chromosome Mapping Polymorphism, Genetic

Chemicals

Genetic Markers

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Kong X

Department of Genetics, Rutgers University, Piscataway, NJ 08840, USA.

Murphy K

Raj T

He C

White P S

Matise T C

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Article Info

Journal

American journal of human genetics

Abbr.

Am J Hum Genet

ISSN

0002-9297

DOI

10.1086/426405

Published

2004-12-00

Epub

2004-00-14

Pages

1143-8

Language

English

Region

United States

NLM ID

0370475

PMCID

PMC1182151

Subset

Grants

NHGRI NIH HHS · HG01691 · United States

NIMH NIH HHS · MH60240 · United States

Corrections

ErratumIn

External Links

PubMed source DOI: 10.1086/426405 PMC Full Text View journal details

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A combined linkage-physical map of the human genome.

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