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PMID: 15496983 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Mash1 specifies neurons and oligodendrocytes in the postnatal brain.

The EMBO journal ·Vol. 23 ·No. 22 ·2004-11-10 ·Pages 4495-505

Parras CM, Galli R, Britz O, Soares S, Galichet C, Battiste J, Johnson JE, Nakafuku M, Vescovi A, Guillemot F

Abstract

Progenitors in the telencephalic subventricular zone (SVZ) remain mitotically active throughout life, and produce different cell types at embryonic, postnatal and adult stages. Here we show that Mash1, an important proneural gene in the embryonic telencephalon, is broadly expressed in the postnatal SVZ, in progenitors for both neuronal and oligodendrocyte lineages. Moreover, Mash1 is required at birth for the generation of a large fraction of neuronal and oligodendrocyte precursors from the olfactory bulb. Clonal analysis in culture and transplantation experiments in postnatal brain demonstrate that this phenotype reflects a cell-autonomous function of Mash1 in specification of these two lineages. The conservation of Mash1 function in the postnatal SVZ suggests that the same transcription mechanisms operate throughout life to specify cell fates in this structure, and that the profound changes in the cell types produced reflect changes in the signalling environment of the SVZ.

MeSH Terms
Animals Animals, Newborn Basic Helix-Loop-Helix Transcription Factors Brain/cytology Brain Tissue Transplantation Bromodeoxyuridine/metabolism Cell Differentiation Cell Lineage Cells, Cultured Coculture Techniques Crosses, Genetic DNA-Binding Proteins/genetics,metabolism Heterozygote Immunohistochemistry In Situ Hybridization Lac Operon Mice Mice, Mutant Strains Mutation Neuroglia/cytology Neurons/cytology Olfactory Bulb/cytology Stem Cells/physiology Telencephalon/cytology,embryology,transplantation Transcription Factors/genetics,metabolism,physiology Transplantation, Heterotopic
Chemicals
Ascl1 protein, mouse Basic Helix-Loop-Helix Transcription Factors DNA-Binding Proteins Transcription Factors Bromodeoxyuridine
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Parras Carlos M
Institut de Génétique et de Biologie Cellulaire et Moléculaire, Illkirch, France.
Galli Rossella
Britz Olivier
Soares Sylvia
Galichet Christophe
Battiste James
Johnson Jane E
Nakafuku Masato
Vescovi Angelo
Guillemot François
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
DOI
10.1038/sj.emboj.7600447
Published
2004-11-10
Epub
2004-00-21
Pages
4495-505
Language
English
Region
England
NLM ID
8208664
PMCID
PMC526464
Subset
IM
External Links
PubMed source DOI: 10.1038/sj.emboj.7600447 PMC Full Text View journal details
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