Hallmarks of 'BRCAness' in sporadic cancers.

Nature reviews. Cancer ·Vol. 4 ·No. 10 ·2004-00-00 ·Pages 814-9

Turner N, Tutt A, Ashworth A

Abstract

Germline mutations in the BRCA1, BRCA2 and Fanconi anaemia genes confer cancer susceptibility, and the proteins encoded by these genes have distinct functions in related DNA-repair processes. Emerging evidence indicates that these processes are disrupted by numerous mechanisms in sporadic cancers. Collectively, there are properties that define 'BRCAness' - that is, traits that some sporadic cancers share with those occurring in either BRCA1- or BRCA2-mutation carriers. These common properties might have important implications for the clinical management of these cancers.

MeSH Terms

BRCA1 Protein/physiology BRCA2 Protein/physiology Breast Neoplasms/classification,genetics,pathology DNA Damage DNA Repair/genetics DNA, Neoplasm/genetics,metabolism Epigenesis, Genetic Fanconi Anemia/genetics Fanconi Anemia Complementation Group D2 Protein Fanconi Anemia Complementation Group F Protein Female Gene Expression Profiling Genes, BRCA1 Genes, BRCA2 Humans Nuclear Proteins/physiology Phenotype RNA-Binding Proteins/physiology Recombination, Genetic/genetics Sequence Homology, Nucleic Acid

Chemicals

BRCA1 Protein BRCA2 Protein DNA, Neoplasm FANCD2 protein, human FANCF protein, human Fanconi Anemia Complementation Group D2 Protein Fanconi Anemia Complementation Group F Protein Nuclear Proteins RNA-Binding Proteins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Turner Nicholas

The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.

Tutt Andrew

Ashworth Alan

Article Info

Journal

Nature reviews. Cancer

Abbr.

Nat Rev Cancer

ISSN

1474-175X

DOI

10.1038/nrc1457

Published

2004-00-00

Pages

814-9

Language

English

Region

England

NLM ID

101124168

Subset

Grants

Breast Cancer Now · BREAST CANCER NOW RESEARCH CENTRE · United Kingdom

External Links

PubMed source DOI: 10.1038/nrc1457 View journal details

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Hallmarks of 'BRCAness' in sporadic cancers.

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