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PMID: 15522326 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

The role of thrombospondin-1 in human disease.

The Journal of surgical research ·Vol. 122 ·No. 1 ·2004-11-00 ·Pages 135-42

Esemuede N, Lee T, Pierre-Paul D, Sumpio BE, Gahtan V

Abstract

Thrombospondin-1 (TSP-1) is a large matricellular glycoprotein secreted by many cell types. It is a component of the extracellular matrix during active and subacute processes. Due to TSP-1's ability to interact with a variety of matrix proteins and cell-surface receptors, controversy exists about its conflicting functions. In this review, we will discuss the role of TSP-1 in human disease.

MeSH Terms

Disease Disease Progression Humans Neoplasms/physiopathology Neovascularization, Pathologic/metabolism Neovascularization, Physiologic Platelet Aggregation Thrombospondin 1/metabolism Vascular Diseases/physiopathology Wound Healing

Chemicals

Thrombospondin 1

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Esemuede Nowokere

Yale University School of Medicine, New Haven, Connecticut, USA.

Lee Taeseung

Pierre-Paul Daphne

Sumpio Bauer E

Gahtan Vivian

Article Info

Journal

The Journal of surgical research

Abbr.

J Surg Res

ISSN

0022-4804

DOI

10.1016/j.jss.2004.05.015

Published

2004-11-00

Pages

135-42

Language

English

Region

United States

NLM ID

0376340

Subset

External Links

PubMed source DOI: 10.1016/j.jss.2004.05.015 View journal details

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