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PMID: 15539397 Published · ppublish English Journal Article Review

Excitatory and inhibitory connections show selectivity in the neocortex.

The Journal of physiology ·Vol. 562 ·No. Pt 1 ·2005-01-01 ·Pages 89-97

Watts J, Thomson AM

Abstract

The cerebral cortex is pivotal in information processing and higher brain function and its laminar structure of six distinct layers, each in receipt of a different constellation of inputs, makes it important to identify connectivity patterns and distinctions between excitatory and inhibitory pathways. The 'feedforward' projections from layer 4-3 and from 3-5 target pyramidal cells and to lesser degrees interneurones. 'Feedback' projections from layer 5-3 and from 3-4, on the other hand, mainly target interneurones. Understanding the microcircuitry may give some insight into the computation and information processing performed in this brain region.

MeSH Terms
Animals Hippocampus/cytology,physiology Humans Neocortex/cytology,physiology Neural Pathways/physiology Neurons/physiology Pyramidal Cells/physiology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Watts Jo
Department of Pharmacology, School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK. [email protected]
Thomson Alex M
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.2004.076984
Email
[email protected]
Published
2005-01-01
Epub
2004-00-11
Pages
89-97
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1665474
Subset
IM
Grants
Medical Research Council · G0000207 · United Kingdom
External Links
PubMed source DOI: 10.1113/jphysiol.2004.076984 PMC Full Text View journal details
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