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PMID: 15578084 Published · ppublish English Comment Journal Article

PPARs in atherosclerosis: the clot thickens.

The Journal of clinical investigation ·Vol. 114 ·No. 11 ·2004-12-00 ·Pages 1538-40

Castrillo A, Tontonoz P

Abstract

Cardiovascular disease is the leading cause of morbidity and mortality in Western countries. Previous studies have highlighted the beneficial effects of PPARgamma activators on cardiovascular disease; however, the role of other PPAR family members in atherosclerosis is less clear. A report in this issue of the JCI expands our understanding of PPARs in vascular biology and highlights the potential use of multiple PPAR agonists to limit lipid accumulation in macrophages.

MeSH Terms
Animals Arteriosclerosis/metabolism Endothelium, Vascular/metabolism Humans Lipid Metabolism Macrophages/cytology,metabolism Mice Multigene Family Peroxisome Proliferator-Activated Receptors/agonists,metabolism Signal Transduction/physiology
Chemicals
Peroxisome Proliferator-Activated Receptors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Castrillo Antonio
Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, California, USA.
Tontonoz Peter
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI23705
Published
2004-12-00
Pages
1538-40
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC529290
Subset
IM
Corrections
CommentOn
PMID: 15578089
External Links
PubMed source DOI: 10.1172/JCI23705 PMC Full Text View journal details
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