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PMID: 15605990 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Amyloid beta-peptide(1-42) contributes to the oxidative stress and neurodegeneration found in Alzheimer disease brain.

Brain pathology (Zurich, Switzerland) ·Vol. 14 ·No. 4 ·2004-10-00 ·Pages 426-32

Butterfield DA, Boyd-Kimball D

Abstract

Oxidative stress is extensive in Alzheimer disease (AD) brain. Amyloid beta-peptide (1-42) has been shown to induce oxidative stress and neurotoxicity in vitro and in vivo. Genetic mutations that result in increased production of Abeta1-42 from amyloid precursor protein are associated with an early onset and accelerated pathology of AD. Consequently, Abeta1-42 has been proposed to play a central role in the pathogenesis of AD as a mediator of oxidative stress. In this review, we discuss the role of Abeta1-42 in the lipid peroxidation and protein oxidation evident in AD brain and the implications of such oxidative stress for the function of various proteins that we have identified as specifically oxidized in AD brain compared to control, using proteomics methods. Additionally, we discuss the critical role of methionine 35 in the oxidative stress and neurotoxic properties exhibited by Abeta1-42.

MeSH Terms
Alzheimer Disease/complications,metabolism Amyloid beta-Peptides/chemistry,toxicity Animals Humans Lipid Peroxidation/drug effects,physiology Methionine/metabolism Models, Neurological Nerve Degeneration/complications,metabolism Oxidative Stress/drug effects,physiology Peptide Fragments/chemistry,toxicity
Chemicals
Amyloid beta-Peptides Peptide Fragments amyloid beta-protein (1-42) Methionine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Butterfield D Allan
Department of Chemistry, Center for Membrane Sciences, University of Kentucky, Lexington, 40506-0055, USA. [email protected]
Boyd-Kimball Debra
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Article Info
Journal
Brain pathology (Zurich, Switzerland)
Abbr.
Brain Pathol
ISSN
1015-6305
DOI
10.1111/j.1750-3639.2004.tb00087.x
Email
[email protected]
Published
2004-10-00
Pages
426-32
Language
English
Region
Switzerland
NLM ID
9216781
PMCID
PMC8096022
Subset
IM
Grants
NIA NIH HHS · AG 05119 · United States
NIA NIH HHS · AG 10836 · United States
External Links
PubMed source DOI: 10.1111/j.1750-3639.2004.tb00087.x PMC Full Text View journal details
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