Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.

Angiogenesis Inhibitors/therapeutic use Angiopoietin-1/physiology Animals Antibodies, Monoclonal/pharmacology,therapeutic use Antigens/analysis Apoptosis/drug effects,radiation effects Basement Membrane/drug effects,metabolism,pathology Blood Vessels/chemistry,drug effects,radiation effects Blotting, Western Brain Neoplasms/drug therapy,metabolism,radiotherapy Cell Line, Tumor Cell Movement/drug effects Collagen Type IV/analysis,genetics,metabolism Combined Modality Therapy/methods Dipeptides/pharmacology Ephrin-B2/genetics Fluorescein Angiography Gamma Rays/therapeutic use Gene Expression Regulation, Neoplastic/drug effects Glioma/drug therapy,metabolism,radiotherapy Humans Immunohistochemistry Male Matrix Metalloproteinase Inhibitors Matrix Metalloproteinases/metabolism Mice Mice, Nude Models, Biological Neovascularization, Pathologic/drug therapy,radiotherapy Oligonucleotide Array Sequence Analysis Oxygen/metabolism Pericytes/chemistry,cytology,physiology Proteoglycans/analysis Receptor, TIE-2/antagonists & inhibitors,immunology Time Factors Transfection Up-Regulation/genetics Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors,immunology,metabolism Xenograft Model Antitumor Assays

Angiogenesis Inhibitors Angiopoietin-1 Antibodies, Monoclonal Antigens Collagen Type IV Dipeptides Ephrin-B2 Matrix Metalloproteinase Inhibitors N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide Proteoglycans chondroitin sulfate proteoglycan 4 Receptor, TIE-2 Vascular Endothelial Growth Factor Receptor-2 Matrix Metalloproteinases Oxygen