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PMID: 1563775 Published · ppublish English Journal Article

Nucleotide sequence of the ospAB operon of a Borrelia burgdorferi strain expressing OspA but not OspB.

Infection and immunity ·Vol. 60 ·No. 5 ·1992-05-00 ·Pages 1864-8

Eiffert H, Ohlenbusch A, Fehling W, Lotter H, Thomssen R

Abstract

The nucleotide sequence of a 1.6-kb clone containing the gene for outer surface protein A (OspA) of a German strain (GO2) of Borrelia burgdorferi was determined. The deduced amino acid sequence showed a homology of 82% to the OspA molecules from three other B. burgdorferi strains. The best-conserved region was recognized at the 36-amino-terminal amino acids of OspA. OspB could not be identified in the strain investigated, probably because the nucleotide sequence of the ospAB operon prevented expression of the OspB gene.

MeSH Terms
Amino Acid Sequence Animals Bacterial Outer Membrane Proteins/genetics Base Sequence Borrelia burgdorferi Group/genetics Cloning, Molecular Molecular Sequence Data Operon Rabbits
Chemicals
Bacterial Outer Membrane Proteins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Eiffert H
Department of Medical Microbiology, University of Göttingen, Germany.
Ohlenbusch A
Fehling W
Lotter H
Thomssen R
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.60.5.1864-1868.1992
Published
1992-05-00
Pages
1864-8
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC257086
Subset
IM
Databases
GENBANK
M63610, M63611, M63612, M63613, M63614, M63615, M63616, M63617, X60300, X63185
External Links
PubMed source DOI: 10.1128/iai.60.5.1864-1868.1992 PMC Full Text View journal details
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