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PMID: 15662004 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Mitochondrial dysfunction and type 2 diabetes.

Science (New York, N.Y.) ·Vol. 307 ·No. 5708 ·2005-01-21 ·Pages 384-7

Lowell BB, Shulman GI

Abstract

Maintenance of normal blood glucose levels depends on a complex interplay between the insulin responsiveness of skeletal muscle and liver and glucose-stimulated insulin secretion by pancreatic beta cells. Defects in the former are responsible for insulin resistance, and defects in the latter are responsible for progression to hyperglycemia. Emerging evidence supports the potentially unifying hypothesis that both of these prominent features of type 2 diabetes are caused by mitochondrial dysfunction.

MeSH Terms
Adenosine Triphosphate Animals Diabetes Mellitus, Type 2/physiopathology Fatty Acids/metabolism Gene Expression Regulation Glucose/metabolism Humans Hyperglycemia/physiopathology Insulin/metabolism Insulin Resistance Insulin Secretion Ion Channels Islets of Langerhans/cytology,metabolism,physiology Liver/metabolism Membrane Transport Proteins/genetics,metabolism Mitochondria/physiology Mitochondrial Proteins/genetics,metabolism Models, Biological Muscle, Skeletal/metabolism Obesity/physiopathology Oxidation-Reduction Oxidative Phosphorylation Superoxides/metabolism Transcription Factors/metabolism Uncoupling Protein 2
Chemicals
Fatty Acids Insulin Ion Channels Membrane Transport Proteins Mitochondrial Proteins Transcription Factors Uncoupling Protein 2 peroxisome-proliferator-activated receptor-gamma coactivator-1 Superoxides Adenosine Triphosphate Glucose
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lowell Bradford B
Department of Medicine, Beth Israel Deaconess Medical Center, 99 Brookline Avenue, Harvard Medical School, Boston, MA 02215, USA. [email protected]
Shulman Gerald I
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
DOI
10.1126/science.1104343
Email
[email protected]
Published
2005-01-21
Pages
384-7
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
NIDDK NIH HHS · R01 DK040936 · United States
External Links
PubMed source DOI: 10.1126/science.1104343 View journal details
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