Natural HIV-1 NEF accelerates virus replication in primary human lymphocytes.

Virology ·Vol. 188 ·No. 1 ·1992-05-00 ·Pages 391-5

de Ronde A, Klaver B, Keulen W, Smit L, Goudsmit J

Abstract

HIV-1 NEF genes were isolated directly from peripheral blood lymphocyte DNA of two HIV-1-infected individuals and cloned into an HXB-2-infectious molecular clone. The effect of NEF on virus production in T-cell lines and primary human lymphocytes was studied. Naturally occurring NEF accelerates virus production in primary human lymphocytes, but not in T-cell lines.

Related Genes

NEF

MeSH Terms

Amino Acid Sequence Base Sequence Cells, Cultured Cloning, Molecular DNA, Viral Gene Products, nef/chemistry,genetics Genes, nef HIV Long Terminal Repeat HIV-1/genetics,physiology Humans Kinetics Lymphocytes/microbiology Molecular Sequence Data Restriction Mapping Sequence Alignment T-Lymphocytes/microbiology Virus Replication/genetics nef Gene Products, Human Immunodeficiency Virus

Chemicals

DNA, Viral Gene Products, nef nef Gene Products, Human Immunodeficiency Virus

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

de Ronde A

University of Amsterdam, Academic Medical Centre, Amsterdam.

Klaver B

Keulen W

Smit L

Goudsmit J

Article Info

Journal

Virology

Abbr.

Virology

ISSN

0042-6822

DOI

10.1016/0042-6822(92)90772-h

Published

1992-05-00

Pages

391-5

Language

English

Region

United States

NLM ID

0110674

Subset

Databases

GENBANK

M84627, M84628, M84629, M84630, M84631, M84632

External Links

PubMed source DOI: 10.1016/0042-6822(92)90772-h View journal details

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Natural HIV-1 NEF accelerates virus replication in primary human lymphocytes.

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