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PMID: 15705809 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Comparison of fine-scale recombination rates in humans and chimpanzees.

Science (New York, N.Y.) ·Vol. 308 ·No. 5718 ·2005-04-01 ·Pages 107-11

Winckler W, Myers SR, Richter DJ, Onofrio RC, McDonald GJ, Bontrop RE, McVean GA, Gabriel SB, Reich D, Donnelly P, Altshuler D

Abstract

We compared fine-scale recombination rates at orthologous loci in humans and chimpanzees by analyzing polymorphism data in both species. Strong statistical evidence for hotspots of recombination was obtained in both species. Despite approximately 99% identity at the level of DNA sequence, however, recombination hotspots were found rarely (if at all) at the same positions in the two species, and no correlation was observed in estimates of fine-scale recombination rates. Thus, local patterns of recombination rate have evolved rapidly, in a manner disproportionate to the change in DNA sequence.

MeSH Terms
Alleles Animals Base Sequence Chromosome Mapping Chromosomes, Human/genetics Chromosomes, Mammalian/genetics Evolution, Molecular Genome Genome, Human Genotype Globins/genetics HLA Antigens/genetics Haplotypes Humans Linkage Disequilibrium Markov Chains Monte Carlo Method Pan troglodytes/genetics Polymorphism, Single Nucleotide Recombination, Genetic Sequence Homology, Nucleic Acid
Chemicals
HLA Antigens Globins
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Winckler Wendy
Department of Molecular Biology and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114-2622, USA.
Myers Simon R
Richter Daniel J
Onofrio Robert C
McDonald Gavin J
Bontrop Ronald E
McVean Gilean A T
Gabriel Stacey B
Reich David
Donnelly Peter
Altshuler David
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
DOI
10.1126/science.1105322
Published
2005-04-01
Epub
2005-00-10
Pages
107-11
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Corrections
CommentIn
PMID: 15802591
External Links
PubMed source DOI: 10.1126/science.1105322 View journal details
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