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PMID: 15710736 Published · ppublish English Letter Research Support, Non-U.S. Gov't

Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension.

Heart (British Cardiac Society) ·Vol. 91 ·No. 3 ·2005-03-00 ·Pages 391-2

Fukumoto Y, Matoba T, Ito A, Tanaka H, Kishi T, Hayashidani S, Abe K, Takeshita A, Shimokawa H

Abstract

暂无摘要

MeSH Terms

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/administration & dosage,analogs & derivatives Adult Aged Female Humans Hypertension, Pulmonary/drug therapy,physiopathology Infusions, Intravenous Intracellular Signaling Peptides and Proteins Male Middle Aged Protein Kinase Inhibitors/administration & dosage Protein Serine-Threonine Kinases/antagonists & inhibitors Treatment Outcome Vasodilation/physiology Vasodilator Agents/administration & dosage rho-Associated Kinases

Chemicals

Intracellular Signaling Peptides and Proteins Protein Kinase Inhibitors Vasodilator Agents 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine Protein Serine-Threonine Kinases rho-Associated Kinases fasudil

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Fukumoto Y

Matoba T

Ito A

Tanaka H

Kishi T

Hayashidani S

Abe K

Takeshita A

Shimokawa H

References (5)

5 references, click to expand

Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II.
J Physiol. 2000 Jan 15;522 Pt 2:177-85 PMID: 10639096
Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans.
Hypertension. 2001 Dec 1;38(6):1307-10 PMID: 11751708
Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats.
Circ Res. 2004 Feb 20;94(3):385-93 PMID: 14670839
Primary pulmonary hypertension.
Lancet. 2003 May 3;361(9368):1533-44 PMID: 12737878
Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases.
J Cardiovasc Pharmacol. 2002 Mar;39(3):319-27 PMID: 11862109

Article Info

Journal

Heart (British Cardiac Society)

Abbr.

Heart

ISSN

1468-201X

DOI

10.1136/hrt.2003.029470

Published

2005-03-00

Pages

391-2

Language

English

Region

England

NLM ID

9602087

PMCID

PMC1768747

Subset

External Links

PubMed source DOI: 10.1136/hrt.2003.029470 PMC Full Text View journal details

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Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension.

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