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PMID: 15718304 Published · epublish English Journal Article Research Support, Non-U.S. Gov't

Relative predicted protein levels of functionally associated proteins are conserved across organisms.

Nucleic acids research ·Vol. 33 ·No. 3 ·2005-00-00 ·Pages 1051-7

Lithwick G, Margalit H

Abstract

We show that the predicted protein levels of functionally related proteins change in a coordinated fashion over many unicellular organisms. For each protein, we created a profile containing a protein abundance measure in each of a set of organisms. We show that for functionally related proteins these profiles tend to be correlated. Using the Codon Adaptation Index as a predictor of protein abundance in 48 unicellular organisms, we demonstrated this phenomenon for two types of functional relations: for proteins that physically interact and for proteins involved in consecutive steps within a metabolic pathway. Our results suggest that the protein abundance levels of functionally related proteins co-evolve.

MeSH Terms
Archaeal Proteins/analysis,genetics,metabolism Bacterial Proteins/analysis,genetics,metabolism Codon Databases, Genetic Evolution, Molecular Fungal Proteins/analysis,genetics,metabolism Genomics/methods Proteins/analysis,genetics,metabolism
Chemicals
Archaeal Proteins Bacterial Proteins Codon Fungal Proteins Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lithwick Gila
Department of Molecular Genetics and Biotechnology, The Faculty of Medicine, The Hebrew University Jerusalem 91120, Israel.
Margalit Hanah
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
1362-4962
DOI
10.1093/nar/gki261
Published
2005-00-00
Epub
2005-00-17
Pages
1051-7
Language
English
Region
England
NLM ID
0411011
PMCID
PMC549420
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/gki261 PMC Full Text View journal details
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