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PMID: 15738417 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 102 ·No. 10 ·2005-03-08 ·Pages 3714-9

Pearton DJ, Yang Y, Dhouailly D

Abstract

Differentiated cells of the corneal epithelium are converted to hair, along with their associated stem cells, then interfollicular epidermis, by means of a multistep process triggered by dermal developmental signals. The committed basal cells of the adult corneal epithelium dedifferentiate under the control of signals from an associated embryonic hair-forming dermis, likely Wnts, and revert to a limbal basal cell phenotype. This initial process involves the down-regulation of Pax6 and the loss of expression of corneal-specific keratins and the induction of basal keratinocyte markers. These dedifferentiated cells are able to reinduce dermal condensations, which in turn induce the formation of hair follicles from cells that have lost Pax6 expression, by means of a Noggin-dependent mechanism. An epidermis is subsequently formed by cells derived from the newly segregated hair stem cells.

MeSH Terms
Animals Carrier Proteins Cell Differentiation Cell Division Cell Fusion Cytoskeletal Proteins/biosynthesis DNA-Binding Proteins/biosynthesis Epidermal Cells Epithelium, Corneal/cytology Eye Proteins Hair Follicle/cytology Homeodomain Proteins/physiology Intercellular Signaling Peptides and Proteins/physiology Keratins/biosynthesis Lymphoid Enhancer-Binding Factor 1 Mice Mice, Nude PAX6 Transcription Factor Paired Box Transcription Factors Proteins/physiology Rabbits Repressor Proteins Stem Cells/physiology Trans-Activators/biosynthesis Transcription Factors/biosynthesis Wnt Proteins beta Catenin
Chemicals
CTNNB1 protein, mouse Carrier Proteins Cytoskeletal Proteins DNA-Binding Proteins Eye Proteins Homeodomain Proteins Intercellular Signaling Peptides and Proteins Lymphoid Enhancer-Binding Factor 1 PAX6 Transcription Factor Paired Box Transcription Factors Pax6 protein, mouse Proteins Repressor Proteins Trans-Activators Transcription Factors Wnt Proteins beta Catenin noggin protein Keratins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Pearton David J
Equipe Biologie de la Différenciation Epithéliale, UMR-CNRS 5538, Laboratoire d'Etude de la Différentiation et de l'Adhérence Cellulaire, Institut Albert Bonniot, Université Joseph Fourier, BP 53-38041 Grenoble Cedex 9, France.
Yang Ying
Dhouailly Danielle
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.0500344102
Published
2005-03-08
Epub
2005-00-28
Pages
3714-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC553311
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.0500344102 PMC Full Text View journal details
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