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PMID: 15765131 Published · ppublish English Journal Article Review

Oxygen, oxidative stress, hypoxia, and heart failure.

The Journal of clinical investigation ·Vol. 115 ·No. 3 ·2005-03-00 ·Pages 500-8

Giordano FJ

Abstract

A constant supply of oxygen is indispensable for cardiac viability and function. However, the role of oxygen and oxygen-associated processes in the heart is complex, and they and can be either beneficial or contribute to cardiac dysfunction and death. As oxygen is a major determinant of cardiac gene expression, and a critical participant in the formation of ROS and numerous other cellular processes, consideration of its role in the heart is essential in understanding the pathogenesis of cardiac dysfunction.

MeSH Terms
Animals Calcium/metabolism Cardiac Output, Low/pathology,physiopathology Energy Metabolism Gene Expression Regulation Humans Hypertrophy Hypoxia/metabolism Ion Channels/metabolism Lipids/toxicity Mitochondria/metabolism Myocardial Ischemia/metabolism Myocardium/cytology,metabolism,pathology Oxidative Stress Oxygen/metabolism Reactive Oxygen Species/metabolism Signal Transduction/physiology
Chemicals
Ion Channels Lipids Reactive Oxygen Species Oxygen Calcium
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Giordano Frank J
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA. [email protected]
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI24408
Email
[email protected]
Published
2005-03-00
Pages
500-8
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC1052012
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI24408 PMC Full Text View journal details
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