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PMID: 15765138 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Death begets failure in the heart.

The Journal of clinical investigation ·Vol. 115 ·No. 3 ·2005-03-00 ·Pages 565-71

Foo RS, Mani K, Kitsis RN

Abstract

Recently, low--but abnormal--rates of cardiomyocyte apoptosis have been observed in failing human hearts. Genetic and pharmacological studies suggest that this cell death is causally linked to heart failure in rodent models. Herein, we review these data and discuss potential therapeutic implications.

MeSH Terms
Animals Apoptosis/physiology Cardiac Output, Low/metabolism,pathology,therapy Humans Myocytes, Cardiac/cytology,metabolism Signal Transduction/physiology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Foo Roger S-Y
Department of Medicine, Cardiovascular Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Mani Kartik
Kitsis Richard N
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI24569
Published
2005-03-00
Pages
565-71
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC1052022
Subset
IM
Grants
NHLBI NIH HHS · R01 HL073732 · United States
NHLBI NIH HHS · R01 HL061550 · United States
NHLBI NIH HHS · R01 HL060665 · United States
NHLBI NIH HHS · R01 HL73732 · United States
NHLBI NIH HHS · R01 HL61550 · United States
NHLBI NIH HHS · R01 HL60665 · United States
External Links
PubMed source DOI: 10.1172/JCI24569 PMC Full Text View journal details
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