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PMID: 1577736 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Intron-exon organization of the NF-Y genes. Tissue-specific splicing modifies an activation domain.

The Journal of biological chemistry ·Vol. 267 ·No. 13 ·1992-05-05 ·Pages 8984-90

Li XY, Hooft van Huijsduijnen R, Mantovani R, Benoist C, Mathis D

Abstract

NF-Y is a highly conserved transcription factor which recognizes CCAAT motifs in a variety of genes. We report here the genomic organization of the genes encoding both subunits, which gives interesting clues about the functional organization of the proteins. We also report the existence of isoforms of NF-YA which result from differential splicing. These alternative splicing events map within a glutamine-rich activation domain and show a marked cell- and tissue-specific bias.

Related Genes
MeSH Terms
Amino Acid Sequence Animals Base Sequence CCAAT-Enhancer-Binding Proteins Cell Line Chloramphenicol O-Acetyltransferase/genetics,metabolism DNA/genetics DNA-Binding Proteins/genetics Exons Introns Mice Molecular Sequence Data Plasmids Polymerase Chain Reaction Protein Biosynthesis RNA Splicing Sequence Homology, Nucleic Acid Transcription Factors/genetics Transcription, Genetic
Chemicals
CCAAT-Enhancer-Binding Proteins DNA-Binding Proteins Transcription Factors DNA Chloramphenicol O-Acetyltransferase
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Li X Y
Laboratoire de Génétique Moléculaire des Eucaryotes du Centre National de la Recherche Scientifique, Unité 184 de Biologie Moléculaire, Strasbourg, France.
Hooft van Huijsduijnen R
Mantovani R
Benoist C
Mathis D
Article Info
Journal
The Journal of biological chemistry
Abbr.
J Biol Chem
ISSN
0021-9258
Published
1992-05-05
Pages
8984-90
Language
English
Region
United States
NLM ID
2985121R
Subset
IM
Databases
GENBANK
L06145, M74318, M74319, M74320, M74321, M74322, M74323, M74324, M86214, M86215
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