The kinase domain of titin controls muscle gene expression and protein turnover.

Amino Acid Sequence Amino Acid Substitution Animals Catalytic Domain Cell Line Cell Nucleus/metabolism Connectin Gene Expression Regulation Heat-Shock Proteins/metabolism Humans Intracellular Signaling Peptides and Proteins Ligands Mice Mice, Inbred C3H Molecular Sequence Data Muscle Proteins/chemistry,genetics,metabolism Muscle, Skeletal/metabolism Muscular Diseases/genetics Mutation Myocytes, Cardiac/metabolism Protein Binding Protein Conformation Protein Kinases/chemistry,genetics,metabolism Protein Structure, Tertiary Proteins/metabolism Rats Respiratory Insufficiency/genetics,metabolism Sarcomeres/metabolism Sequestosome-1 Protein Serum Response Factor/metabolism Signal Transduction Two-Hybrid System Techniques Ubiquitin-Protein Ligases/metabolism

Connectin Heat-Shock Proteins Intracellular Signaling Peptides and Proteins Ligands Muscle Proteins NBR1 protein, human Nbr1 protein, rat Proteins Sequestosome-1 Protein Serum Response Factor Sqstm1 protein, rat TTN protein, human Ubiquitin-Protein Ligases Protein Kinases