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PMID: 158362 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Serum-serum interactions in autoimmune mice.

Arthritis and rheumatism ·Vol. 22 ·No. 10 ·1979-10-00 ·Pages 1074-81

Eisenberg RA, Thor LT, Dixon FJ

Abstract

Sera from a majority of old, sick mice of the MRL/l strain interact with other MRL/l sera to form visible immunoprecipitates and fix complement. The mouse sera can be divided into two sets such that interset interactions are far more common than intraset ones. The reactive principle in each mouse serum is IgG in the form of an intermediate-sized complex. Reactivity between sera is dependent on IgG anti-IgG specificities.

MeSH Terms

Animals Autoimmune Diseases/immunology Centrifugation, Density Gradient Chemical Precipitation Chromatography, Affinity Glomerulonephritis/immunology Immune Complex Diseases/immunology Immunodiffusion Immunoglobulin G/analysis Methods Mice Mice, Inbred Strains/immunology Pepsin A Peptide Hydrolases Radioimmunoassay Rheumatoid Factor/analysis Ribonucleases

Chemicals

Immunoglobulin G Rheumatoid Factor Ribonucleases Peptide Hydrolases Pepsin A

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Eisenberg R A

Thor L T

Dixon F J

Article Info

Journal

Arthritis and rheumatism

Abbr.

Arthritis Rheum

ISSN

0004-3591

DOI

10.1002/art.1780221005

Published

1979-10-00

Pages

1074-81

Language

English

Region

United States

NLM ID

0370605

Subset

External Links

PubMed source DOI: 10.1002/art.1780221005 View journal details

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