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PMID: 15897982 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S.

Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels.

American journal of human genetics ·Vol. 77 ·No. 1 ·2005-07-00 ·Pages 64-77

Carlson CS, Aldred SF, Lee PK, Tracy RP, Schwartz SM, Rieder M, Liu K, Williams OD, Iribarren C, Lewis EC, Fornage M, Boerwinkle E, Gross M, Jaquish C, Nickerson DA, Myers RM, Siscovick DS, Reiner AP

Abstract

Elevated plasma levels of C-reactive protein (CRP), an inflammation-sensitive marker, have emerged as an important predictor of future cardiovascular disease and metabolic abnormalities in apparently healthy men and women. Here, we performed a systematic survey of common nucleotide variation across the genomic region encompassing the CRP gene locus. Of the common single-nucleotide polymorphisms (SNPs) identified, several in the CRP promoter region are strongly associated with CRP levels in a large cohort study of cardiovascular risk in European American and African American young adults. We also demonstrate the functional importance of these SNPs in vitro.

MeSH Terms
Adolescent Base Sequence C-Reactive Protein/genetics,metabolism Female Gene Frequency Haplotypes Humans Male Polymorphism, Genetic Polymorphism, Single Nucleotide Promoter Regions, Genetic
Chemicals
C-Reactive Protein
Authors & Affiliations
18 authors, click to expand affiliations / ORCID
Carlson Christopher S
Department of Genome Sciences, University of Washington, Seattle, WA, USA. [email protected]
Aldred Shelley Force
Lee Philip K
Tracy Russell P
Schwartz Stephen M
Rieder Mark
Liu Kiang
Williams O Dale
Iribarren Carlos
Lewis E Cora
Fornage Myriam
Boerwinkle Eric
Gross Myron
Jaquish Cashell
Nickerson Deborah A
Myers Richard M
Siscovick David S
Reiner Alexander P
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
DOI
10.1086/431366
Email
[email protected]
Published
2005-07-00
Epub
2005-00-16
Pages
64-77
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1226195
Subset
IM
Grants
NHLBI NIH HHS · U01 HL066642 · United States
NHLBI NIH HHS · R01 HL071017 · United States
NHLBI NIH HHS · N01-HC-05187 · United States
NHLBI NIH HHS · HL71017 · United States
NHLBI NIH HHS · N01-HC-48047 · United States
NHLBI NIH HHS · N01HC48049 · United States
NHLBI NIH HHS · N01-HC-95095 · United States
NHLBI NIH HHS · N01-HC-48050 · United States
NHLBI NIH HHS · N01HC95095 · United States
NHLBI NIH HHS · N01-HC-48049 · United States
NHLBI NIH HHS · N01 HC045134 · United States
NHLBI NIH HHS · N01HC48050 · United States
NHLBI NIH HHS · N01HC05187 · United States
NHLBI NIH HHS · N01HC48047 · United States
NHLBI NIH HHS · HL66682 · United States
NHLBI NIH HHS · N01-HC-48048 · United States
NHLBI NIH HHS · HL66642 · United States
NHLBI NIH HHS · U01 HL066682 · United States
NHLBI NIH HHS · N01HC48048 · United States
Corrections
ErratumIn
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External Links
PubMed source DOI: 10.1086/431366 PMC Full Text View journal details
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