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PMID: 1590255 Published · ppublish English Journal Article Review

Comparative life spans of species: why do species have the life spans they do?

The American journal of clinical nutrition ·Vol. 55 ·No. 6 Suppl ·1992-00-00 ·Pages 1191S-1195S

Kirkwood TB

Abstract

Proximate answers to questions about species longevity are to be found in the physiological processes that regulate duration of life. But what are these processes, and how are they themselves controlled? This leads to ultimate, evolutionary questions about longevity. What are the selection forces that favor one life span instead of another for a given species? To understand the evolution of life span we need also to understand the evolution of aging. A plausible hypothesis is that because of the requirement for reproduction, natural selection favors a strategy that invests fewer resources in maintenance of somatic cells and tissues than are necessary for indefinite survival. This "disposable soma" theory predicts that aging is due to the accumulation of unrepaired somatic defects and the primary genetic control of longevity operates through selection to raise or lower the investment in basic cellular maintenance systems in relation to the level of environmental hazard.

MeSH Terms
Aging/genetics,physiology Animals Biological Evolution Humans Longevity/genetics,physiology Reproduction/physiology Species Specificity
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kirkwood T B
Laboratory of Mathematical Biology, National Institute for Medical Research, London, UK.
Article Info
Journal
The American journal of clinical nutrition
Abbr.
Am J Clin Nutr
ISSN
0002-9165
Published
1992-00-00
Pages
1191S-1195S
Language
English
Region
United States
NLM ID
0376027
Subset
IM
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