The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro.

Antimicrobial agents and chemotherapy ·Vol. 36 ·No. 1 ·1992-01-00 ·Pages 202-5

Coates JA, Cammack N, Jenkinson HJ, Mutton IM, Pearson BA, Storer R, Cameron JM, Penn CR

Abstract

Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog having a sulfur atom in place of the 3' carbon. The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2. However, the (-)-enantiomer (3TC) is considerably less cytotoxic than the (+)-enantiomer.

MeSH Terms

Antiviral Agents/pharmacology Cells, Cultured Chromatography, High Pressure Liquid Cytosine/analogs & derivatives,pharmacology HIV-1/drug effects HIV-2/drug effects Humans Lamivudine Stereoisomerism Structure-Activity Relationship Virus Replication/drug effects

Chemicals

Antiviral Agents Lamivudine Cytosine

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Coates J A

Department of Virology, Glaxo Group Research Ltd., Greenford, Middlesex, United Kingdom.

Cammack N

Jenkinson H J

Mutton I M

Pearson B A

Storer R

Cameron J M

Penn C R

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14 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.36.1.202

Published

1992-01-00

Pages

202-5

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC189255

Subset

External Links

PubMed source DOI: 10.1128/AAC.36.1.202 PMC Full Text View journal details

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The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro.

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