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PMID: 15915326 Published · ppublish English Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Linkage analysis of a completely ascertained sample of familial schizophrenics and bipolars from Palau, Micronesia.

Human genetics ·Vol. 117 ·No. 4 ·2005-08-00 ·Pages 349-56

Klei L, Bacanu SA, Myles-Worsley M, Galke B, Xie W, Tiobech J, Otto C, Roeder K, Devlin B, Byerley W

Abstract

We report on linkage analysis of a completely ascertained population of familial psychosis derived from the oceanic nation of Palau. Palau, an archipelago of islands in the Southern Pacific, currently has a population of approximately 23,000 individuals. The peoples of Palau populated these islands recently in human history, approximately 2,000 years ago. As both historical and genetic evidence suggest, the population is far more homogeneous than most other populations undergoing genetic studies, and should therefore prove quite useful for mapping genetic variants having a meaningful impact on susceptibility to psychotic disorders. Moreover, for our study, essentially all on-island schizophrenics (150) and individuals with other psychotic disorders (25) participated. By analysis of narrow (only schizophrenia) and broad (all psychosis) diagnostic schemes, two-point linkage analyses suggest that two regions of the genome harbor genetic variants affecting liability in most families, 3q28 (LOD = 3.03) and 17q32.2 (LOD = 2.80). Results from individual pedigrees also support 2q37.2, 2p14, and 17p13 as potentially harboring important genetic variants. Most of these regions have been implicated in other genetic studies of psychosis in populations physically quite distant from this Oceanic population, although some (e.g., 3q28) appear to be novel results for schizophrenia linkage analyses.

MeSH Terms
Bipolar Disorder/genetics Chromosomes, Human, Pair 17/genetics Chromosomes, Human, Pair 3/genetics Genetic Linkage Humans Lod Score Microsatellite Repeats/genetics Palau/epidemiology Pedigree Schizophrenia/epidemiology,genetics
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Klei Lambertus
Department of Statistics, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Bacanu Silviu-Alin
Myles-Worsley Marina
Galke Brandi
Xie Weiting
Tiobech Josepha
Otto Caleb
Roeder Kathyrn
Devlin Bernie
Byerley William
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/s00439-005-1320-1
Published
2005-08-00
Epub
2005-00-25
Pages
349-56
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
Grants
NIMH NIH HHS · MH063295 · United States
NIMH NIH HHS · R01 MH057881 · United States
NIMH NIH HHS · MH057881 · United States
NIMH NIH HHS · MH063356 · United States
NHGRI NIH HHS · N01-HG-65403 · United States
External Links
PubMed source DOI: 10.1007/s00439-005-1320-1 View journal details
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