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PMID: 15946 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Antibacterial product of peritoneal exudate cell cultures from guinea pigs infected with mycobacteria, listeriae, and rickettsiae.

Infection and immunity ·Vol. 15 ·No. 3 ·1977-03-00 ·Pages 745-50

Sharma SD, Middlebrook G

Abstract

In an in vitro model of cellular immunity, the antibacterial product of immunologically mediated mononuclear cell activation was studied from guinea pigs infected with listeriae and rickettsiae and compared with the product previously described from animals infected with mycobacteria. We found that this product, active against gram-positive bacilli, appeared to be identical in the three different infections with regard to its heat stability, its chromatographic adsorption and elution pattern, its susceptibility to inactivation by proteolytic enzymes, and its antibacterial spectrum

MeSH Terms
Animals Antigens, Bacterial Ascitic Fluid/cytology Guinea Pigs Hydrogen-Ion Concentration Listeriosis/immunology Lymphocytes/immunology Lymphokines Macrophages/immunology Mycobacterium Infections/immunology Rickettsia Infections/immunology Temperature
Chemicals
Antigens, Bacterial Lymphokines
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sharma S D
Middlebrook G
References (22)
22 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.15.3.745-750.1977
Published
1977-03-00
Pages
745-50
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC421433
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.15.3.745-750.1977 PMC Full Text View journal details
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