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PMID: 15947178 Published · ppublish English Journal Article Review

Latest advances in understanding preeclampsia.

Science (New York, N.Y.) ·Vol. 308 ·No. 5728 ·2005-06-10 ·Pages 1592-4

Redman CW, Sargent IL

Abstract

Preeclampsia is a relatively common pregnancy disorder that originates in the placenta and causes variable maternal and fetal problems. In the worst cases, it may threaten the survival of both mother and baby. We summarize recent work on the causes of preeclampsia, which reveals a new mode of maternal immune recognition of the fetus, relevant to the condition. The circulating factors derived from the placenta, which contributes to the clinical syndrome, are now better understood. This brief review on preeclampsia does not cover all aspects of this intriguing condition but focuses on some new and interesting findings.

MeSH Terms
Animals Female Fetal Development HLA Antigens/analysis Humans Inflammation Killer Cells, Natural/immunology Oxidative Stress Placenta/blood supply,physiology,physiopathology Placentation Pre-Eclampsia/etiology,immunology,physiopathology Pregnancy Proteins/metabolism,pharmacology Trophoblasts/immunology,physiology
Chemicals
HLA Antigens Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Redman Christopher W
Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK. [email protected]
Sargent Ian L
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
Published
2005-06-10
Pages
1592-4
Language
English
Region
United States
NLM ID
0404511
Subset
IM
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