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PMID: 15950006 Published · ppublish English Journal Article Meta-Analysis Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S. Review

Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review.

Biological psychiatry ·Vol. 57 ·No. 11 ·2005-06-01 ·Pages 1336-46

Willcutt EG, Doyle AE, Nigg JT, Faraone SV, Pennington BF

Abstract

One of the most prominent neuropsychologic theories of attention-deficit/hyperactivity disorder (ADHD) suggests that its symptoms arise from a primary deficit in executive functions (EF), defined as neurocognitive processes that maintain an appropriate problem-solving set to attain a later goal. To examine the validity of the EF theory, we conducted a meta-analysis of 83 studies that administered EF measures to groups with ADHD (total N = 3734) and without ADHD (N = 2969). Groups with ADHD exhibited significant impairment on all EF tasks. Effect sizes for all measures fell in the medium range (.46-.69), but the strongest and most consistent effects were obtained on measures of response inhibition, vigilance, working memory, and planning. Weaknesses in EF were significant in both clinic-referred and community samples and were not explained by group differences in intelligence, academic achievement, or symptoms of other disorders. ADHD is associated with significant weaknesses in several key EF domains. However, moderate effect sizes and lack of universality of EF deficits among individuals with ADHD suggest that EF weaknesses are neither necessary nor sufficient to cause all cases of ADHD. Difficulties with EF appear to be one important component of the complex neuropsychology of ADHD.

MeSH Terms
Algorithms Attention Deficit Disorder with Hyperactivity/physiopathology Cognition/physiology Cognition Disorders/etiology Humans Models, Psychological Neuropsychological Tests Problem Solving/physiology Reproducibility of Results
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Willcutt Erik G
Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA. [email protected]
Doyle Alysa E
Nigg Joel T
Faraone Stephen V
Pennington Bruce F
Article Info
Journal
Biological psychiatry
Abbr.
Biol Psychiatry
ISSN
0006-3223
Published
2005-06-01
Pages
1336-46
Language
English
Region
United States
NLM ID
0213264
Subset
IM
Grants
NIMH NIH HHS · K08-MH-66072 · United States
NIMH NIH HHS · MH 04024 · United States
NIMH NIH HHS · MH 38820 · United States
NIMH NIH HHS · MH 59105 · United States
NIMH NIH HHS · MH 62120 · United States
NIMH NIH HHS · MH 63941 · United States
NIMH NIH HHS · R21MH/NS66191 · United States
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