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PMID: 15959516 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Notch signals control the fate of immature progenitor cells in the intestine.

Nature ·Vol. 435 ·No. 7044 ·2005-06-16 ·Pages 964-8

Fre S, Huyghe M, Mourikis P, Robine S, Louvard D, Artavanis-Tsakonas S

Abstract

The Notch signalling pathway plays a crucial role in specifying cellular fates in metazoan development by regulating communication between adjacent cells. Correlative studies suggested an involvement of Notch in intestinal development. Here, by modulating Notch activity in the mouse intestine, we directly implicate Notch signals in intestinal cell lineage specification. We also show that Notch activation is capable of amplifying the intestinal progenitor pool while inhibiting cell differentiation. We conclude that Notch activity is required for the maintenance of proliferating crypt cells in the intestinal epithelium.

MeSH Terms
Animals Apoptosis Basic Helix-Loop-Helix Transcription Factors Cell Differentiation Cell Lineage Cell Proliferation DNA-Binding Proteins/genetics Epithelial Cells/cytology,metabolism Female Gene Expression Regulation Homeodomain Proteins/genetics,metabolism Integrases/genetics,metabolism Intestinal Mucosa/metabolism Intestines/cytology Male Mice Mice, Transgenic Nerve Tissue Proteins/genetics RNA, Messenger/genetics,metabolism Receptor, Notch1 Receptors, Cell Surface/genetics,metabolism Signal Transduction Stem Cells/cytology,metabolism Transcription Factor HES-1 Transcription Factors/genetics,metabolism Viral Proteins/genetics,metabolism
Chemicals
Atoh1 protein, mouse Basic Helix-Loop-Helix Transcription Factors DNA-Binding Proteins Hes1 protein, mouse Homeodomain Proteins Nerve Tissue Proteins Neurog3 protein, mouse Notch1 protein, mouse RNA, Messenger Receptor, Notch1 Receptors, Cell Surface Transcription Factor HES-1 Transcription Factors Viral Proteins Cre recombinase Integrases
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Fre Silvia
Department of Cell Biology, Harvard Medical School, Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA.
Huyghe Mathilde
Mourikis Philippos
Robine Sylvie
Louvard Daniel
Artavanis-Tsakonas Spyros
Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature03589
Published
2005-06-16
Pages
964-8
Language
English
Region
England
NLM ID
0410462
Subset
IM
External Links
PubMed source DOI: 10.1038/nature03589 View journal details
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