Home LiteratureArticle Details
PMID: 1599309 Published · ppublish English Journal Article Review

Biological role of lactoferrin.

Archives of disease in childhood ·Vol. 67 ·No. 5 ·1992-05-00 ·Pages 657-61

Sánchez L, Calvo M, Brock JH

Abstract

暂无摘要

MeSH Terms
Animals Bacteria/growth & development Humans Inflammation/physiopathology Iron/metabolism Lactoferrin/immunology,metabolism,physiology Milk, Human/chemistry
Chemicals
Iron Lactoferrin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Sánchez L
Department of Food Technology and Biochemistry, Veterinary Faculty, University of Zaragoza, Spain.
Calvo M
Brock J H
References (56)
56 references, click to expand
  1. Immunoreactive lactoferrin in resting, activated, and neoplastic lymphocytes.
    Leuk Res. 1990;14(5):441-7 PMID: 2189046
  2. Isolation and partial characterization of a lactotransferrin receptor from mouse intestinal brush border.
    Biochemistry. 1990 Jan 16;29(2):535-41 PMID: 2154249
  3. Iron is not required in the lactoferrin stimulation of thymidine incorporation into the DNA of rat crypt enterocytes.
    Pediatr Res. 1990 May;27(5):525-8 PMID: 2345681
  4. Molecular forms of lactoferrin in stool and urine from infants fed human milk.
    Pediatr Res. 1990 Mar;27(3):252-5 PMID: 2320391
  5. Mineral excretion during acute, dehydrating diarrhea treated with oral rehydration therapy.
    Pediatr Res. 1990 Feb;27(2):170-5 PMID: 2314946
  6. Lactoferrin deficiency as a consequence of a lack of specific granules in neutrophils from a patient with recurrent infections. Detection by immunoperoxidase staining for lactoferrin and cytochemical electron microscopy.
    Am J Pathol. 1980 May;99(2):413-28 PMID: 6155073
  7. [Changes in the bacteriostatic activity of lactoferrin during lactation and following experimental infection of the udder with Staphylococcus aureus].
    Zentralbl Veterinarmed A. 1982 Aug;29(6):405-19 PMID: 6814126
  8. Bactericidal activity of human lactoferrin: differentiation from the stasis of iron deprivation.
    Infect Immun. 1982 Mar;35(3):792-9 PMID: 6802759
  9. Local passive transfer of delayed-type hypersensitivity in the mouse.
    J Immunol. 1982 Jul;129(1):25-9 PMID: 6177751
  10. Iron withholding: a defense against infection and neoplasia.
    Physiol Rev. 1984 Jan;64(1):65-102 PMID: 6420813
  11. [Effect of orally administered bovine lactoferrin and bovine IgG on the establishment of Escherichia coli in the digestive tract of gnotobiotic mice and human newborn infants].
    Ann Microbiol (Paris). 1983 Nov-Dec;134B(3):429-41 PMID: 6372577
  12. The effect of trypsin and chymotrypsin on the in vitro antimicrobial and iron-binding properties of lactoferrin in human milk and bovine colostrum. Unusual resistance of human apolactoferrin to proteolytic digestion.
    Biochim Biophys Acta. 1983 Sep 13;759(3):229-35 PMID: 6349699
  13. Supplementation of milk with iron bound to lactoferrin using weanling mice: L. Effects on hematology and tissue iron.
    J Pediatr Gastroenterol Nutr. 1983 Nov;2(4):693-700 PMID: 6644450
  14. Characterization and properties of the human and bovine lactotransferrins extracted from the faeces of newborn infants.
    Acta Paediatr Scand. 1982 Nov;71(6):979-85 PMID: 6818832
  15. Lactoferrin in human milk: its role in iron absorption and protection against enteric infection in the newborn infant.
    Arch Dis Child. 1980 Jun;55(6):417-21 PMID: 7002055
  16. In vitro studies of lactoferrin and murine granulopoiesis.
    Blood. 1981 Mar;57(3):574-8 PMID: 6970054
  17. Lactoferrin-mediated modulation of mononuclear cell activities. I. Suppression of the murine in vitro primary antibody responses.
    Cell Immunol. 1981 Sep 15;63(2):308-20 PMID: 7196805
  18. The role of lactoferrin in the bactericidal function of polymorphonuclear leucocytes.
    Immunology. 1979 Apr;36(4):781-91 PMID: 108208
  19. Identification of lactoferrin as the granulocyte-derived inhibitor of colony-stimulating activity production.
    J Exp Med. 1978 Oct 1;148(4):1052-67 PMID: 308988
  20. Lactoferrin in milk from different species.
    Comp Biochem Physiol B. 1971 May 15;39(1):119-29 PMID: 4998849
  21. The involvement of lactoferrin in the hyposideremia of acute inflammation.
    J Exp Med. 1974 Oct 1;140(4):1068-84 PMID: 4214890
  22. Iron-binding proteins in milk and resistance to Escherichia coli infection in infants.
    Br Med J. 1972 Jan 8;1(5792):69-75 PMID: 4550126
  23. RIBONUCLEASE OF BOVINE MILK: PURIFICATION AND PROPERTIES.
    Arch Biochem Biophys. 1964 Jul 20;106:235-9 PMID: 14217163
  24. Lysozyme, lactoferrin, and secretory immunoglobulin A content in breast milk: influence of duration of lactation, nutrition status, prolactin status, and parity of mother.
    Am J Clin Nutr. 1991 Jan;53(1):32-9 PMID: 1984349
  25. Lactoferrin activates plasma membrane oxidase and Na+/H+ antiport activity.
    Biochem Biophys Res Commun. 1991 Apr 15;176(1):498-504 PMID: 1850271
  26. Origin of intact lactoferrin and its DNA-binding fragments found in the urine of human milk-fed preterm infants. Evaluation by stable isotopic enrichment.
    Pediatr Res. 1991 Mar;29(3):243-50 PMID: 1903521
  27. Expression of cloned human lactoferrin in baby-hamster kidney cells.
    Biochem J. 1991 Jun 1;276 ( Pt 2):349-55 PMID: 2049066
  28. Iron availability from an infant formula supplemented with bovine lactoferrin.
    Acta Paediatr Scand. 1991 Feb;80(2):155-8 PMID: 2035305
  29. Structurally intact (78-kDa) forms of maternal lactoferrin purified from urine of preterm infants fed human milk: identification of a trypsin-like proteolytic cleavage event in vivo that does not result in fragment dissociation.
    Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):2994-8 PMID: 2014220
  30. Lactoferrin-inducible monocyte cytotoxicity for K562 cells and decay of natural killer lymphocyte cytotoxicity.
    Clin Exp Immunol. 1991 Jan;83(1):154-6 PMID: 1988223
  31. Lactoferrin and transferrin damage of the gram-negative outer membrane is modulated by Ca2+ and Mg2+.
    J Gen Microbiol. 1990 Jul;136(7):1437-46 PMID: 2230724
  32. Specific binding of lactoferrin to brush-border membrane: ontogeny and effect of glycan chain.
    Am J Physiol. 1988 Apr;254(4 Pt 1):G580-5 PMID: 2833117
  33. Visualization of lactotransferrin brush-border receptors by ligand-blotting.
    Biochim Biophys Acta. 1985 Dec 19;821(3):453-60 PMID: 3000447
  34. Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Are lactoferrin and transferrin promoters of hydroxyl-radical generation?
    Biochem J. 1987 Jan 1;241(1):273-8 PMID: 3032157
  35. Protective influence of lactoferrin on mice infected with the polycythemia-inducing strain of Friend virus complex.
    Cancer Res. 1987 Aug 1;47(15):4184-8 PMID: 3038309
  36. Human milk-derived lactoferrin inhibits mitogen and alloantigen induced human lymphocyte proliferation.
    J Reprod Immunol. 1987 Oct;12(2):137-48 PMID: 2963123
  37. Lactoferrin derived from neutrophils inhibits the mixed lymphocyte reaction.
    Blood. 1987 May;69(5):1328-33 PMID: 2952183
  38. Lactoferrin effects of phagocytic cell function. II. The presence of iron is required for the lactoferrin molecule to stimulate intracellular killing by macrophages but not to enhance the uptake of particles and microorganisms.
    J Immunol. 1987 Sep 1;139(5):1647-51 PMID: 3114372
  39. Fe-saturation and proteolysis of human lactoferrin: effect on brush-border receptor-mediated uptake of Fe and Mn.
    Am J Physiol. 1989 Dec;257(6 Pt 1):G930-4 PMID: 2558579
  40. The N-terminal domain I of human lactotransferrin binds specifically to phytohemagglutinin-stimulated peripheral blood human lymphocyte receptors.
    FEBS Lett. 1989 Sep 11;255(1):201-4 PMID: 2551729
  41. Expression of human lactotransferrin receptors in phytohemagglutinin-stimulated human peripheral blood lymphocytes. Isolation of the receptors by antiligand-affinity chromatography.
    Eur J Biochem. 1989 Feb 1;179(2):481-7 PMID: 2537213
  42. Lactoferrin can protect mice against a lethal dose of Escherichia coli in experimental infection in vivo.
    Br J Exp Pathol. 1989 Dec;70(6):697-704 PMID: 2690922
  43. Enzyme immunoassay of lactoferrin in newborn term infants: reference values and influence of diet.
    Ann Clin Biochem. 1989 Sep;26 ( Pt 5):407-11 PMID: 2683971
  44. Breast-milk IgA and lactoferrin survival in the gastrointestinal tract--a study in rural Gambian children.
    Acta Paediatr Scand. 1989 Jul;78(4):505-12 PMID: 2782064
  45. Immunocytochemical detection of lactoferrin in human gastric carcinomas and adenomas.
    Arch Pathol Lab Med. 1989 Aug;113(8):912-5 PMID: 2757492
  46. Multiple molecular forms of human lactoferrin. Identification of a class of lactoferrins that possess ribonuclease activity and lack iron-binding capacity.
    J Exp Med. 1989 Aug 1;170(2):415-29 PMID: 2754391
  47. Gastric luminal digestion of lactoferrin and transferrin by preterm infants.
    Early Hum Dev. 1989 May;19(2):127-35 PMID: 2737103
  48. Interleukin 1 administration in mice produces hypoferremia despite neutropenia.
    J Clin Invest. 1988 Dec;82(6):1934-8 PMID: 3264289
  49. Concentration of lactoferrin and transferrin throughout lactation in cow's colostrum and milk.
    Biol Chem Hoppe Seyler. 1988 Sep;369(9):1005-8 PMID: 3228487
  50. Biochemical and antibacterial properties of bovine mammary secretion during mammary involution and at parturition.
    J Dairy Sci. 1984 Dec;67(12):2863-72 PMID: 6397483
  51. Lactoferrin: no evidence for its role in regulation of CSA production by human lymphocytes and monocytes.
    Blood Cells. 1984;10(2-3):369-95 PMID: 6336166
  52. Lactoferrin and iron absorption in newborn infants.
    Pediatr Res. 1987 Dec;22(6):651-4 PMID: 3431946
  53. Breast milk lactoferrin levels in relation to maternal nutritional status.
    J Pediatr Gastroenterol Nutr. 1985 Apr;4(2):230-3 PMID: 3886869
  54. Comparison of human lactoferrins from milk and neutrophilic leucocytes. Relative molecular mass, isoelectric point, iron-binding properties and uptake by the liver.
    Biochem J. 1985 Jul 15;229(2):353-9 PMID: 4038272
  55. Primary structure of glycans isolated from human leucocyte lactotransferrin. Absence of fucose residues questions the proposed mechanism of hyposideraemia.
    Biochem J. 1990 Aug 1;269(3):821-5 PMID: 2390069
  56. Nucleotide sequence of human lactoferrin cDNA.
    Nucleic Acids Res. 1990 Jul 11;18(13):4013 PMID: 2374734
Article Info
Journal
Archives of disease in childhood
Abbr.
Arch Dis Child
ISSN
1468-2044
DOI
10.1136/adc.67.5.657
Published
1992-05-00
Pages
657-61
Language
English
Region
England
NLM ID
0372434
PMCID
PMC1793702
Subset
IM
External Links
PubMed source DOI: 10.1136/adc.67.5.657 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2