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PMID: 16039572 Published · ppublish English Comment Journal Article Review

Divide and conquer: division of labor by B-1 B cells.

Immunity ·Vol. 23 ·No. 1 ·2005-07-00 ·Pages 1-2

Alugupalli KR, Gerstein RM

Abstract

Capsular polysaccharides enhance bacterial virulence. In this issue of Immunity, demonstrate a division of labor between the B-1 B cell subsets: natural antibodies from B-1a cells limit infection by Streptococcus pneumoniae, whereas B-1b cells generate the anticapsule-induced response that prevents fatal infection.

MeSH Terms
Animals B-Lymphocyte Subsets/immunology Bacterial Capsules/immunology Mice Streptococcus pneumoniae/immunology,pathogenicity Virulence
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Alugupalli Kishore R
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA.
Gerstein Rachel M
Article Info
Journal
Immunity
Abbr.
Immunity
ISSN
1074-7613
DOI
10.1016/j.immuni.2005.07.001
Published
2005-07-00
Pages
1-2
Language
English
Region
United States
NLM ID
9432918
Subset
IM
Corrections
CommentOn
PMID: 16039575
External Links
PubMed source DOI: 10.1016/j.immuni.2005.07.001 View journal details
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