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PMID: 1605617 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The multidrug efflux transporter of Bacillus subtilis is a structural and functional homolog of the Staphylococcus NorA protein.

Antimicrobial agents and chemotherapy ·Vol. 36 ·No. 2 ·1992-02-00 ·Pages 484-5

Neyfakh AA

Abstract

The Bacillus subtilis multidrug efflux transporter Bmr demonstrates 44% amino acid sequence identity with a product of the Staphylococcus aureus gene norA, which is responsible for clinically relevant resistance to fluoroquinolones. We show here that overexpression of bmr in B. subtilis provides strong resistance to fluoroquinolones that can be reversed by reserpine, an inhibitor of Bmr.

MeSH Terms
Amino Acid Sequence Bacillus subtilis/genetics,metabolism Bacterial Proteins/analysis,metabolism Carrier Proteins Membrane Transport Proteins Molecular Sequence Data Multidrug Resistance-Associated Proteins Reserpine/pharmacology Sequence Homology, Nucleic Acid Staphylococcus aureus/genetics,metabolism
Chemicals
Bacterial Proteins Carrier Proteins Membrane Transport Proteins Multidrug Resistance-Associated Proteins NorA protein, Staphylococcus Bmr protein, Bacillus subtilis Reserpine
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Neyfakh A A
Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago 60680.
References (5)
5 references, click to expand
  1. Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones.
    J Bacteriol. 1990 Dec;172(12):6942-9 PMID: 2174864
  2. Endogenous active efflux of norfloxacin in susceptible Escherichia coli.
    Antimicrob Agents Chemother. 1988 Aug;32(8):1187-91 PMID: 3056253
  3. Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system.
    Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4781-5 PMID: 1675788
  4. Accumulation of biological amines into chromaffin granules: a model for hormone and neurotransmitter transport.
    Physiol Rev. 1988 Jan;68(1):232-307 PMID: 2892215
  5. Effects of indole alkaloids on multidrug resistance and labeling of P-glycoprotein by a photoaffinity analog of vinblastine.
    Biochem Biophys Res Commun. 1988 Jun 30;153(3):959-66 PMID: 2898941
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.36.2.484
Published
1992-02-00
Pages
484-5
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC188464
Subset
IM
Databases
GENBANK
M33768
External Links
PubMed source DOI: 10.1128/AAC.36.2.484 PMC Full Text View journal details
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