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PMID: 1608303 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Nitric oxide, an inhibitor of lipid oxidation by lipoxygenase, cyclooxygenase and hemoglobin.

Lipids ·Vol. 27 ·No. 1 ·1992-01-00 ·Pages 46-9

Kanner J, Harel S, Granit R

Abstract

The present study demonstrated that nitric oxide, which is an important mammalian metabolite, can inhibit oxidation by lipoxygenase, cyclooxygenase and hemoglobin. The inhibition is manifested as a lag-phase that is reversible. The inhibitory effect of nitric oxide on lipoxygenase and cyclooxygenase seems to derive from i) the capability of .NO to reduce the ferric enzyme to the ferrous form, which is inactive; ii) competition for the iron site available for exogenous ligands; and iii) the radical scavenging ability of the nitroxide radical. Nitric oxide may act as a modulator of the arachidonic acid cascade and in the generation of oxygen-active species.

MeSH Terms
Animals Carotenoids/metabolism Cattle Hemoglobins/metabolism Linoleic Acid Linoleic Acids/metabolism Lipid Peroxidation Lipoxygenase/metabolism Male Methemoglobin/metabolism Microsomes/metabolism Nitric Oxide/pharmacology Oxidation-Reduction Oxygenases/metabolism Prostaglandin-Endoperoxide Synthases/metabolism Seminal Vesicles/metabolism beta Carotene
Chemicals
Hemoglobins Linoleic Acids beta Carotene Nitric Oxide Carotenoids Methemoglobin Linoleic Acid Oxygenases Lipoxygenase Prostaglandin-Endoperoxide Synthases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kanner J
Department of Food Science, Volcani Center, Bet Dagan, Israel.
Harel S
Granit R
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Article Info
Journal
Lipids
Abbr.
Lipids
ISSN
0024-4201
DOI
10.1007/BF02537058
Published
1992-01-00
Pages
46-9
Language
English
Region
United States
NLM ID
0060450
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02537058 View journal details
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