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PMID: 16094982 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Bacterial mutants able to partly suppress the effect of N mutations in bacteriophage lambda.

Molecular & general genetics : MGG ·Vol. 136 ·No. 2 ·1975-00-00 ·Pages 167-80

Brunel F, Davison J

Abstract

A method is described whereby bacterial mutants (sun) may be selected which are able to specifically suppress mutations in the N gene of bacteriophage lambda. The sun mutations seem to be allelic to suA mutations, which suppress the polarity of nonsense codons, since suA mutants have all of the properties of sun mutants and both are genetically linked to the ilv gene. In the light of these experiments and recent data by others, models originally suggested to explain polarity in bacterial operons, are discussed with regard to their possible relevance to the mechanism of N action.

MeSH Terms
Bacteriophage lambda/genetics Genes, Viral Mutation Operon Suppression, Genetic
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Brunel F
Department of Molecular Biology, University of Edinburgh.
Davison J
References (38)
38 references, click to expand
  1. Loss of dispensable endonuclease activity in relief of polarity by suA.
    Nat New Biol. 1971 Jun 16;231(24):214-7 PMID: 4932570
  2. Relationship between the N function of bacteriophage lambda and host RNA polymerase.
    J Mol Biol. 1972 Mar 28;65(2):259-72 PMID: 5040359
  3. Studies of novel transducing variants of lambda: dispensability of genes N and Q.
    Virology. 1969 Oct;39(2):348-52 PMID: 5344297
  4. RESTORATION OF OPERON ACTIVITY BY SUPPRESSORS.
    Biochim Biophys Acta. 1963 Sep 17;76:162-4 PMID: 14068553
  5. The beginning of a genetic analysis of recombination proficiency.
    J Cell Physiol. 1967 Oct;70(2):Suppl:165-80 PMID: 4867583
  6. Termination factor for RNA synthesis.
    Nature. 1969 Dec 20;224(5225):1168-74 PMID: 4902144
  7. Hyper-labile messenger RNA in polar mutants of the tryptophan operon of Escherichia coli.
    J Mol Biol. 1972 Dec 14;72(1):103-10 PMID: 4567396
  8. The role of the N gene of phage lambda in the synthesis of two phage-specific proteins.
    Proc Natl Acad Sci U S A. 1968 Jun;60(2):707-12 PMID: 4973489
  9. A bacterial mutation which affects recognition of the N gene product of bacteriophage lambda.
    Mol Gen Genet. 1970;108(4):374-5 PMID: 4924699
  10. Evidence for premature termination of transcription of the tryptophan operon in polarity mutants of Escherichia coli.
    Nature. 1970 Oct 17;228(5268):232-5 PMID: 4920918
  11. Plasmid formation: a new mode of lysogeny by phase lambda.
    Nature. 1969 Jul 12;223(5202):158-60 PMID: 5791722
  12. Polarity and enzyme functions in mutants of the first three genes of the tryptophan operon of Escherichia coli.
    Genetics. 1971 Dec;69(4):409-33 PMID: 4945859
  13. Regulation of lambda exonuclease synthesis: role of the N gene product and lambda repressor.
    J Mol Biol. 1970 Apr 28;49(2):515-9 PMID: 4915096
  14. Studies of the messenger RNA of bacteriophage lambda, I. Various species synthesized early after induction of the prophage.
    Proc Natl Acad Sci U S A. 1968 Nov;61(3):1013-20 PMID: 5246538
  15. Orientation and control of transcription in E. coli phage lambda.
    Nature. 1969 Mar 1;221(5183):823-5 PMID: 5765054
  16. Interference with the expression of the N gene function of phage lambda in a mutant of Escherichia coli.
    Virology. 1973 Jan;51(1):216-26 PMID: 4567743
  17. Isolation and characterization of new sus (amber) mutants of bacteriophage lambda.
    Mutat Res. 1967 Nov-Dec;4(6):735-41 PMID: 5591286
  18. Regulation of lambda exonuclease. II. Joint regulation of exonuclease and a new lambda antigen.
    J Mol Biol. 1966 Jul;18(2):251-61 PMID: 4961270
  19. Genetics of the left arm of the chromosome of bacteriophage lambda.
    Genetics. 1968 Jul;59(3):311-25 PMID: 5705826
  20. Gene regulation in N mutants of bacteriophage lambda.
    J Virol. 1972 Jun;9(6):938-45 PMID: 4556510
  21. Mechanism of transcription in the N operon of bacteriophage lambda.
    Mol Gen Genet. 1972;117(1):72-81 PMID: 4560678
  22. Relief of polarity in E. coli by "suA".
    Nature. 1970 Apr 4;226(5240):28-31 PMID: 4907561
  23. Transduction of linked genetic characters of the host by bacteriophage P1.
    Virology. 1955 Jul;1(2):190-206 PMID: 13267987
  24. Regulation of the enzymes of the tryptophan pathway in Escherichia coli.
    Genetics. 1965 Dec;52(6):1303-16 PMID: 5327408
  25. Quantitative aspects of gene expression in a lambda-trp fusion operon.
    Mol Gen Genet. 1974 Apr 9;130(1):9-20 PMID: 4837659
  26. Altered reading of genetic signals fused to the N operon of bacteriophage lambda: genetic evidence for modification of polymerase by the protein product of the N gene.
    J Mol Biol. 1974 Oct 15;89(1):33-48 PMID: 4613856
  27. Amber suA mutations which relieve polarity.
    J Mol Biol. 1972 Feb 14;63(3):605-8 PMID: 4552413
  28. Regulation of mRNA utilization and degradation by amino-acid starvation.
    Nat New Biol. 1971 Aug 11;232(2):165-9 PMID: 4936599
  29. Genetic control of transcription during development of phage gamma.
    Proc Natl Acad Sci U S A. 1967 Aug;58(2):576-83 PMID: 4860753
  30. Mutants of Escherichia coli K-12 defective in DNA repair and in genetic recombination.
    Genetics. 1966 Jun;53(6):1137-50 PMID: 5335129
  31. Polarity and the degradation of mRNA.
    Nature. 1969 Oct 25;224(5217):329-31 PMID: 4898925
  32. Translation and transcription of the tryptophan operon.
    Prog Nucleic Acid Res Mol Biol. 1973;13:339-407 PMID: 4573491
  33. Formation of aromatic amino acid pools in Escherichia coli K-12.
    J Bacteriol. 1970 Oct;104(1):177-88 PMID: 4919744
  34. Studies on defective lysogeny due to chromosomal deletion in Escherichia coli. I. Single lysogens.
    Biken J. 1966 Jun;9(2):77-87 PMID: 5330517
  35. A role for the product of gene suA in restoration of polarity in vitro.
    Mol Gen Genet. 1973 Aug 28;124(4):345-58 PMID: 4583609
  36. Mutations of coliphage lambda affecting the expression of replicative functions O and P.
    Mol Gen Genet. 1970;108(3):266-76 PMID: 5475574
  37. Release of polarity in Escherichia coli by gene N of phage lambda: termination and antitermination of transcription.
    Proc Natl Acad Sci U S A. 1974 Jun;71(6):2534-8 PMID: 4601822
  38. Positive and negative control of transcription in bacteriophage lambda.
    Br Med Bull. 1973 Sep;29(3):208-13 PMID: 4807323
Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
Published
1975-00-00
Pages
167-80
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
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