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PMID: 16106031 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S.

Tools and strategies for physiological genomics: the Rat Genome Database.

Physiological genomics ·Vol. 23 ·No. 2 ·2005-10-17 ·Pages 246-56

Twigger SN, Pasko D, Nie J, Shimoyama M, Bromberg S, Campbell D, Chen J, dela Cruz N, Fan C, Foote C, Harris G, Hickmann B, Ji Y, Jin W, Li D, Mathis J, Nenasheva N, Nigam R, Petri V, Reilly D, Ruotti V, Schauberger E, Seiler K, Slyper R, Smith J, Wang W, Wu W, Zhao L, Zuniga-Meyer A, Tonellato PJ, Kwitek AE, Jacob HJ

Abstract

The broad goal of physiological genomics research is to link genes to their functions using appropriate experimental and computational techniques. Modern genomics experiments enable the generation of vast quantities of data, and interpretation of this data requires the integration of information derived from many diverse sources. Computational biology and bioinformatics offer the ability to manage and channel this information torrent. The Rat Genome Database (RGD; http://rgd.mcw.edu) has developed computational tools and strategies specifically supporting the goal of linking genes to their functional roles in rat and, using comparative genomics, to human and mouse. We present an overview of the database with a focus on these unique computational tools and describe strategies for the use of these resources in the area of physiological genomics.

MeSH Terms
Animals Cloning, Molecular Databases, Genetic Gene Expression Profiling Genome/genetics Genomics/methods Rats/genetics,physiology
Authors & Affiliations
32 authors, click to expand affiliations / ORCID
Twigger Simon N
Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Pasko Dean
Nie Jeff
Shimoyama Mary
Bromberg Susan
Campbell Dan
Chen Jiali
dela Cruz Norberto
Fan Chunyu
Foote Cindy
Harris Glenn
Hickmann Brian
Ji Yuan
Jin Weihong
Li Dawei
Mathis Jedidiah
Nenasheva Nataliya
Nigam Rajni
Petri Victoria
Reilly Dorothy
Ruotti Victor
Schauberger Eric
Seiler Kathy
Slyper Ronit
Smith Jennifer
Wang Weiye
Wu Wenhua
Zhao Lan
Zuniga-Meyer Angela
Tonellato Peter J
Kwitek Anne E
Jacob Howard J
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Article Info
Journal
Physiological genomics
Abbr.
Physiol Genomics
ISSN
1531-2267
DOI
10.1152/physiolgenomics.00040.2005
Published
2005-10-17
Epub
2005-00-16
Pages
246-56
Language
English
Region
United States
NLM ID
9815683
PMCID
PMC4505745
Subset
IM
Grants
NHLBI NIH HHS · R01 HL064541 · United States
NHGRI NIH HHS · U41 HG002273 · United States
NHLBI NIH HHS · HL-64541 · United States
NHLBI NIH HHS · P50 HL054998 · United States
NHLBI NIH HHS · R01 HL064541-04 · United States
NHGRI NIH HHS · HG-002273 · United States
NHGRI NIH HHS · R01 HG002273 · United States
NHGRI NIH HHS · P41 HG002273 · United States
External Links
PubMed source DOI: 10.1152/physiolgenomics.00040.2005 PMC Full Text View journal details
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