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PMID: 16106067 Published · ppublish English Journal Article Review

Neutrophil homeostasis: a new role for stromal cell-derived factor-1.

Immunologic research ·Vol. 32 ·No. 1-3 ·2005-00-00 ·Pages 169-78

Link DC

Abstract

Neutrophils are a key component of the innate immune response and a major contributor to inflammation. Accordingly, their number in the blood is tightly controlled. Neutrophils are normally produced exclusively in the bone marrow, and their release into the blood is tightly regulated to maintain homeostatic levels in the blood. Herein, recent evidence is reviewed showing that stromal cell-derived factor-1 (SDF-1, CXCL12) plays a key role in regulating neutrophil trafficking in the bone marrow. Moreover, studies are discussed showing that granulocyte colony-stimulating factor, primarily through regulation of SDF-1 expression in the bone marrow, plays an essential role in maintaining neutrophil homeostasis in the blood.

MeSH Terms
Animals Cell Movement/immunology Chemokine CXCL12 Chemokines, CXC/immunology Granulocyte Colony-Stimulating Factor/immunology Homeostasis Humans Immunity, Innate Mice Models, Immunological Mutation Neutropenia/etiology,genetics,immunology Neutrophils/immunology Peptide Hydrolases/immunology Receptors, CXCR4/genetics,immunology Syndrome
Chemicals
CXCL12 protein, human Chemokine CXCL12 Chemokines, CXC Cxcl12 protein, mouse Receptors, CXCR4 Granulocyte Colony-Stimulating Factor Peptide Hydrolases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Link Daniel C
Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA. [email protected]
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Article Info
Journal
Immunologic research
Abbr.
Immunol Res
ISSN
0257-277X
DOI
10.1385/IR:32:1-3:169
Email
[email protected]
Published
2005-00-00
Pages
169-78
Language
English
Region
United States
NLM ID
8611087
Subset
IM
External Links
PubMed source DOI: 10.1385/IR:32:1-3:169 View journal details
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