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PMID: 16141062 Published · ppublish English Comment Journal Article

It's a small RNA world, after all.

Science (New York, N.Y.) ·Vol. 309 ·No. 5740 ·2005-09-02 ·Pages 1525-6

Vaughn MW, Martienssen R

Abstract

Small RNAs (sRNAs) can regulate transcript and protein abundance. Previously, they have been identified using traditional cloning approaches, which has limited how many could be characterized. Now, the Meyers and Green laboratories have used massively parallel signature sequencing technology to find over 1.5 million sRNAs in Arabidopsis thaliana. These new sRNAs reveal a greater-than-expected potential role for sRNAs in gene regulation, preferential expression or usage of sRNAs in flowers, and the prospect of targeted sRNA-mediated regulation of pseudogenes. In addition, new plant microRNAs have been identified, some of which may be unique to Arabidopsis.

MeSH Terms
Arabidopsis/genetics,metabolism Gene Expression Regulation, Plant Genome, Plant Genomics MicroRNAs/physiology RNA, Plant/physiology RNA, Small Interfering/physiology
Chemicals
MicroRNAs RNA, Plant RNA, Small Interfering
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Vaughn Matthew W
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Martienssen Rob
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
Published
2005-09-02
Pages
1525-6
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Corrections
CommentOn
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