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PMID: 16195424 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Bats are natural reservoirs of SARS-like coronaviruses.

Science (New York, N.Y.) ·Vol. 310 ·No. 5748 ·2005-10-28 ·Pages 676-9

Li W, Shi Z, Yu M, Ren W, Smith C, Epstein JH, Wang H, Crameri G, Hu Z, Zhang H, Zhang J, McEachern J, Field H, Daszak P, Eaton BT, Zhang S, Wang LF

Abstract

Severe acute respiratory syndrome (SARS) emerged in 2002 to 2003 in southern China. The origin of its etiological agent, the SARS coronavirus (SARS-CoV), remains elusive. Here we report that species of bats are a natural host of coronaviruses closely related to those responsible for the SARS outbreak. These viruses, termed SARS-like coronaviruses (SL-CoVs), display greater genetic variation than SARS-CoV isolated from humans or from civets. The human and civet isolates of SARS-CoV nestle phylogenetically within the spectrum of SL-CoVs, indicating that the virus responsible for the SARS outbreak was a member of this coronavirus group.

MeSH Terms
Amino Acid Sequence Animals China/epidemiology Chiroptera/virology Chlorocebus aethiops Communicable Diseases, Emerging Coronavirus/classification Disease Outbreaks Disease Reservoirs Genetic Variation Genome, Viral Henipavirus/classification Humans Molecular Sequence Data Mutation Phylogeny Polymerase Chain Reaction SARS Virus/classification Sequence Analysis, DNA Severe Acute Respiratory Syndrome/epidemiology,transmission,virology Vero Cells Viverridae/virology
Authors & Affiliations
17 authors, click to expand affiliations / ORCID
Li Wendong
Institute of Zoology, Chinese Academy of Sciences (CAS), Beijing, China.
Shi Zhengli
Yu Meng
Ren Wuze
Smith Craig
Epstein Jonathan H
Wang Hanzhong
Crameri Gary
Hu Zhihong
Zhang Huajun
Zhang Jianhong
McEachern Jennifer
Field Hume
Daszak Peter
Eaton Bryan T
Zhang Shuyi
Wang Lin-Fa
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
Published
2005-10-28
Epub
2005-00-29
Pages
676-9
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
FIC NIH HHS · R01-TW05869 · United States
Databases
GENBANK
UNKNOWN
Corrections
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