Prediction and validation of microRNAs and their targets.

FEBS letters ·Vol. 579 ·No. 26 ·2005-10-31 ·Pages 5904-10

Bentwich I

Abstract

MicroRNAs are short non-coding RNAs that inhibit translation of target genes by binding to their mRNAs, and have been shown to play a central role in gene regulation in health and disease. Sophisticated computer-based prediction approaches of microRNAs and of their targets, and effective biological validation techniques for validating these predictions, now play a central role in discovery of microRNAs and elucidating their functions.

MeSH Terms

Algorithms Animals Artificial Intelligence Binding Sites Computational Biology Conserved Sequence Evolution, Molecular Humans MicroRNAs/chemistry,physiology Microarray Analysis/methods Models, Biological Models, Genetic RNA/chemistry RNA Interference RNA Precursors RNA, Messenger/metabolism RNA, Plant

Chemicals

MicroRNAs RNA Precursors RNA, Messenger RNA, Plant RNA

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Bentwich Isaac

Rosetta Genomics Ltd., 10 Plaut Street, Science Park, Rehovot 76706, Israel.

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/j.febslet.2005.09.040

Published

2005-10-31

Epub

2005-00-30

Pages

5904-10

Language

English

Region

England

NLM ID

0155157

Subset

External Links

PubMed source DOI: 10.1016/j.febslet.2005.09.040 View journal details

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