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PMID: 16239477 Published · ppublish English Journal Article

Interlinked fast and slow positive feedback loops drive reliable cell decisions.

Science (New York, N.Y.) ·Vol. 310 ·No. 5747 ·2005-10-21 ·Pages 496-8

Brandman O, Ferrell JE, Li R, Meyer T

Abstract

Positive feedback is a ubiquitous signal transduction motif that allows systems to convert graded inputs into decisive, all-or-none outputs. Here we investigate why the positive feedback switches that regulate polarization of budding yeast, calcium signaling, Xenopus oocyte maturation, and various other processes use multiple interlinked loops rather than single positive feedback loops. Mathematical simulations revealed that linking fast and slow positive feedback loops creates a "dual-time" switch that is both rapidly inducible and resistant to noise in the upstream signaling system.

MeSH Terms
Animals Calcium Signaling Cell Physiological Phenomena Computer Simulation Feedback, Physiological Mathematics Models, Biological Oocytes/physiology Phenotype Saccharomycetales/cytology,physiology Signal Transduction Systems Biology Xenopus
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Brandman Onn
Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA, 94305, USA. [email protected]
Ferrell James E
Li Rong
Meyer Tobias
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
DOI
10.1126/science.1113834
Email
[email protected]
Published
2005-10-21
Pages
496-8
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC3175767
Subset
IM
Grants
NIMH NIH HHS · R01 MH064801 · United States
NIGMS NIH HHS · R01 GM063702 · United States
NIGMS NIH HHS · R01 GM046383 · United States
NIGMS NIH HHS · R01 GM030179-24A1 · United States
NIGMS NIH HHS · R01 GM030179 · United States
NIGMS NIH HHS · R01 GM057063 · United States
Corrections
CommentIn
PMID: 16239464
External Links
PubMed source DOI: 10.1126/science.1113834 PMC Full Text View journal details
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