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PMID: 16245073 Published · ppublish English Journal Article Review

Hypothesis: the humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis.

Inflammation ·Vol. 28 ·No. 6 ·2004-12-00 ·Pages 311-8

Rosenstein ED, Greenwald RA, Kushner LJ, Weissmann G

Abstract

Rheumatoid arthritis (RA) and adult periodontitis share common pathogenetic mechanisms and immunologic and pathological findings. One oral pathogen strongly implicated in the pathogenesis of periodontal disease, Porphyromonas gingivalis, possesses a unique microbial enzyme, peptidylarginine deiminase (PAD), the human equivalent of which has been identified as a susceptibility factor for RA. We suggest that individuals predisposed to periodontal infection are exposed to antigens generated by PAD, with de-iminated fibrin as a likely candidate, which become systemic immunogens and lead to intraarticular inflammation. PAD engendered antigens lead to production of rheumatoid factor-containing immune complexes and provoke local inflammation, both in gingiva and synovium via Fc and C5a receptors.

MeSH Terms
Adult Antibody Formation/genetics,immunology Arthritis, Rheumatoid/etiology,immunology,microbiology,pathology Disease Susceptibility/etiology,immunology,microbiology,pathology Humans Hydrolases/immunology,metabolism Models, Biological Mouth Mucosa/microbiology Periodontitis/etiology,microbiology,pathology Porphyromonas gingivalis/enzymology,pathogenicity Protein-Arginine Deiminases Rheumatoid Factor/biosynthesis,immunology Synovial Membrane/immunology
Chemicals
Rheumatoid Factor Hydrolases Protein-Arginine Deiminases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Rosenstein Elliot D
Center for Rheumatic and Autoimmune Diseases, Livingston, New Jersey 07039, USA. [email protected]
Greenwald Robert A
Kushner Laura J
Weissmann Gerald
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Article Info
Journal
Inflammation
Abbr.
Inflammation
ISSN
0360-3997
DOI
10.1007/s10753-004-6641-z
Email
[email protected]
Published
2004-12-00
Pages
311-8
Language
English
Region
United States
NLM ID
7600105
Subset
IM
External Links
PubMed source DOI: 10.1007/s10753-004-6641-z View journal details
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