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PMID: 16279838 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Theta rhythms coordinate hippocampal-prefrontal interactions in a spatial memory task.

PLoS biology ·Vol. 3 ·No. 12 ·2005-12-00 ·Pages e402

Jones MW, Wilson MA

Abstract

Decision-making requires the coordinated activity of diverse brain structures. For example, in maze-based tasks, the prefrontal cortex must integrate spatial information encoded in the hippocampus with mnemonic information concerning route and task rules in order to direct behavior appropriately. Using simultaneous tetrode recordings from CA1 of the rat hippocampus and medial prefrontal cortex, we show that correlated firing in the two structures is selectively enhanced during behavior that recruits spatial working memory, allowing the integration of hippocampal spatial information into a broader, decision-making network. The increased correlations are paralleled by enhanced coupling of the two structures in the 4- to 12-Hz theta-frequency range. Thus the coordination of theta rhythms may constitute a general mechanism through which the relative timing of disparate neural activities can be controlled, allowing specialized brain structures to both encode information independently and to interact selectively according to current behavioral demands.

MeSH Terms
Animals Hippocampus/physiology Male Memory/physiology Prefrontal Cortex/physiology Rats Rats, Long-Evans Space Perception/physiology Theta Rhythm Time Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Jones Matthew W
The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, RIKEN-MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Wilson Matthew A
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Article Info
Journal
PLoS biology
Abbr.
PLoS Biol
ISSN
1545-7885
DOI
10.1371/journal.pbio.0030402
Published
2005-12-00
Epub
2005-00-15
Pages
e402
Language
English
Region
United States
NLM ID
101183755
PMCID
PMC1283536
Subset
IM
Grants
Wellcome Trust · United Kingdom
NIMH NIH HHS · R01 MH061976 · United States
NIMH NIH HHS · R01 MH 61976 · United States
External Links
PubMed source DOI: 10.1371/journal.pbio.0030402 PMC Full Text View journal details
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